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Lgr5 Gene Detail
Summary
  • Symbol
    Lgr5
  • Name
    leucine rich repeat containing G protein coupled receptor 5
  • Synonyms
    Gpr49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341817
    NCBI Gene: 14160
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:115286219-115423685 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 63.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3829 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341817
 protein coding gene Chr10:115286216-115423685 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017739
 protein coding gene Chr10:118161767-118305191 (-)
A/J MGP_AJ_G0017715
 protein coding gene Chr10:113627426-113763137 (-)
AKR/J MGP_AKRJ_G0017677
 protein coding gene Chr10:116918740-117052674 (-)
BALB/cJ MGP_BALBcJ_G0017678
 protein coding gene Chr10:114021062-114159545 (-)
C3H/HeJ MGP_C3HHeJ_G0017503
 protein coding gene Chr10:117147261-117286367 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018135
 protein coding gene Chr10:122269036-122416358 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015815
 protein coding gene Chr10:108251857-108385519 (-)
CAST/EiJ MGP_CASTEiJ_G0017065
 protein coding gene Chr10:117386385-117530282 (-)
CBA/J MGP_CBAJ_G0017472
 protein coding gene Chr10:127034438-127196377 (-)
DBA/2J MGP_DBA2J_G0017577
 protein coding gene Chr10:112776062-112909883 (-)
FVB/NJ MGP_FVBNJ_G0017572
 protein coding gene Chr10:111723579-111860809 (-)
LP/J MGP_LPJ_G0017652
 protein coding gene Chr10:118746089-118888297 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017601
 protein coding gene Chr10:129982835-130136413 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018173
 protein coding gene Chr10:116956574-117097037 (-)
PWK/PhJ MGP_PWKPhJ_G0016847
 protein coding gene Chr10:112845358-112990827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016637
 protein coding gene Chr10:115758702-115904490 (-)
WSB/EiJ MGP_WSBEiJ_G0017125
 protein coding gene Chr10:117132709-117275132 (-)



Homology
more
  • Human Ortholog
    LGR5, leucine rich repeat containing G protein-coupled receptor 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGR5, leucine rich repeat containing G protein-coupled receptor 5
  • Synonyms
    FEX, GPR49, GPR67, GRP49, HG38
  • Links
    NCBI Gene ID: 8549
    neXtProt AC: NX_O75473
    UniProt: O75473

  • Chr Location
    12q21.1; chr12:71439129-71586310 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lgr5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 6 genetic backgrounds
    45 phenotypes from multigenic genotypes
    627 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display 100% neonatal lethality associated with ankyloglossia, gastrointestinal distension, cyanosis and respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1137
  • Tissues
    209
  • cDNA Data
    22
  • Literature Summary
    111
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14160 NCBI Gene Model | MGI Sequence Detail 137467 C57BL/6J ±  kb
    transcript NM_010195 RefSeq | MGI Sequence Detail 4711 C57BL/6  
    polypeptide Q9Z1P4 UniProt | EBI | MGI Sequence Detail 907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000001592 leucine-rich repeat-containing G-protein coupled receptor 5
      (term hierarchy)
    • InterPro Domains
      IPR002131 Glycoprotein hormone receptor family
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
      IPR050328 Multifunctional Developmental and Immune Receptor
    • GlyGen
      Q9Z1P4 4 sites
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 23
      Primer pair 15
      Other 9

      Microarray probesets 5
    References
    more
    • Summaries
      All 738
      Developmental Gene Expression 111
      Diseases 1
      Gene Ontology 11
      Phenotypes 627
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:359304 Lemmetyinen TT, et al., Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation. iScience. 2024 Dec 20;27(12):111246
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory