Mlf1 MGI Mouse Gene Detail - MGI:1341819 - myeloid leukemia factor 1

Symbol

Mlf1
Name

myeloid leukemia factor 1
Synonyms

HLS7

Feature Type

protein coding gene
IDs

MGI:1341819
NCBI Gene: 17349
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr3:67281430-67307333 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 30.91 cM
Mapping Data

3 experiments

SNPs within 2kb

605 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341819	protein coding gene	Chr3:67281430-67307336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027279	protein coding gene	Chr3:66527076-66556804 (+)
A/J	MGP_AJ_G0027241	protein coding gene	Chr3:64576272-64605675 (+)
AKR/J	MGP_AKRJ_G0027209	protein coding gene	Chr3:65944575-65973106 (+)
BALB/cJ	MGP_BALBcJ_G0027252	protein coding gene	Chr3:64437422-64464588 (+)
C3H/HeJ	MGP_C3HHeJ_G0026996	protein coding gene	Chr3:66202060-66228050 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027698	protein coding gene	Chr3:69025044-69053735 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025051	protein coding gene	Chr3:60913434-60939971 (+)
CAST/EiJ	MGP_CASTEiJ_G0026443	protein coding gene	Chr3:66144556-66175695 (+)
CBA/J	MGP_CBAJ_G0026971	protein coding gene	Chr3:71161774-71196267 (+)
DBA/2J	MGP_DBA2J_G0027107	protein coding gene	Chr3:64074827-64103764 (+)
FVB/NJ	MGP_FVBNJ_G0027075	protein coding gene	Chr3:62712817-62738680 (+)
LP/J	MGP_LPJ_G0027215	protein coding gene	Chr3:67463510-67492758 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027094	protein coding gene	Chr3:75829921-75862260 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027756	protein coding gene	Chr3:65838752-65865302 (+)
PWK/PhJ	MGP_PWKPhJ_G0026177	protein coding gene	Chr3:63825034-63852213 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025993	protein coding gene	Chr3:64958274-64983963 (+)
WSB/EiJ	MGP_WSBEiJ_G0026521	protein coding gene	Chr3:65946133-65974745 (+)

Human Ortholog

MLF1, myeloid leukemia factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MLF1, myeloid leukemia factor 1
Links

HGNC:7125

NCBI Gene ID: 4291

neXtProt AC: NX_P58340

UniProt: P58340
Chr Location

3q25.32; chr3:158571163-158607252 (+) GRCh38

MGI Vertebrate Homology

Mlf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MLF1
Gene Tree

Mlf1

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Mlf1
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a null allele exhibit a slight increased B cells in the spleen and decreased ex vivo thymocyte apoptosis susceptibility.

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All GO Annotations

27
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

761
Tissues

25
cDNA Data

70
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mlf1

ZFIN mlf1

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All Sequences

40
RefSeq

4
UniProt

4
CCDS

CCDS17395.1, CCDS17396.1

Ensembl

ENSMUSG00000048416 (Evidence)
NCBI Gene

17349

			Length	Strain/Species	Flank
genomic	17349	NCBI Gene Model \| MGI Sequence Detail	25904	C57BL/6J	± kb
transcript	NM_001039543	RefSeq \| MGI Sequence Detail	1178	ZRU/MplStud
polypeptide	Q9QWV4	UniProt \| EBI \| MGI Sequence Detail	267	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010439 myeloid leukemia factor 1

(term hierarchy)
InterPro Domains

IPR019376 Myeloid leukemia factor

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All nucleic 70

cDNA 70

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 12

Diseases 1

Gene Ontology 10

Phenotypes 9
Earliest

J:56033 Hitzler JK, et al., cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. Am J Pathol. 1999 Jul;155(1):53-9
Latest

J:298990 Sah RK, et al., Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223

TSS for Mlf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29436	Chr3:67281424-67281435 (+)	0 bp
Tssr29437	Chr3:67281449-67281487 (+)	38 bp
Tssr29438	Chr3:67281506-67281518 (+)	82 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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