Trpv2 MGI Mouse Gene Detail - MGI:1341836 - transient receptor potential cation channel, subfamily V, member 2

Symbol

Trpv2
Name

transient receptor potential cation channel, subfamily V, member 2
Synonyms

OTRPC2, Vrl1, VRL-1

Feature Type

protein coding gene
IDs

MGI:1341836
NCBI Gene: 22368
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:62465312-62491131 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 38.48 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

816 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341836	protein coding gene	Chr11:62465312-62491341 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018457	protein coding gene	Chr11:62622212-62648921 (+)
A/J	MGP_AJ_G0018426	protein coding gene	Chr11:60306986-60333333 (+)
AKR/J	MGP_AKRJ_G0018395	protein coding gene	Chr11:62168202-62195197 (+)
BALB/cJ	MGP_BALBcJ_G0018397	protein coding gene	Chr11:60588840-60615941 (+)
C3H/HeJ	MGP_C3HHeJ_G0018210	protein coding gene	Chr11:62148495-62175439 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018849	protein coding gene	Chr11:64600558-64629065 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016494	protein coding gene	Chr11:57397655-57424866 (+)
CAST/EiJ	MGP_CASTEiJ_G0017766	protein coding gene	Chr11:62287889-62317499 (+)
CBA/J	MGP_CBAJ_G0018184	protein coding gene	Chr11:67387898-67415174 (+)
DBA/2J	MGP_DBA2J_G0018293	protein coding gene	Chr11:59868241-59894262 (+)
FVB/NJ	MGP_FVBNJ_G0018283	protein coding gene	Chr11:59535805-59561922 (+)
LP/J	MGP_LPJ_G0018365	protein coding gene	Chr11:63174574-63203354 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018307	protein coding gene	Chr11:68377358-68404586 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018890	protein coding gene	Chr11:62323565-62350295 (+)
PWK/PhJ	MGP_PWKPhJ_G0017540	protein coding gene	Chr11:60486369-60513679 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017330	protein coding gene	Chr11:62165041-62198740 (+)
WSB/EiJ	MGP_WSBEiJ_G0017819	protein coding gene	Chr11:61937899-61964367 (+)

Human Ortholog

TRPV2, transient receptor potential cation channel subfamily V member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRPV2, transient receptor potential cation channel subfamily V member 2
Synonyms

VRL, VRL-1, VRL1
Links

HGNC:18082

NCBI Gene ID: 51393

neXtProt AC: NX_Q9Y5S1

UniProt: Q9Y5S1
Chr Location

17p11.2; chr17:16415571-16437003 (+) GRCh38

MGI Vertebrate Homology

Trpv2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRPV2
Gene Tree

Trpv2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

8
Targeted

6
Genomic Mutations

1 involving Trpv2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection.

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

24
cDNA Data

37
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trpv2

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All Sequences

58
RefSeq

12
UniProt

1
CCDS

CCDS24827.1

Ensembl

ENSMUSG00000018507 (Evidence)
NCBI Gene

22368

			Length	Strain/Species	Flank
genomic	22368	NCBI Gene Model \| MGI Sequence Detail	25820	C57BL/6J	± kb
transcript	NM_001382489	RefSeq \| MGI Sequence Detail	2981	C57BL/6
polypeptide	Q9WTR1	UniProt \| EBI \| MGI Sequence Detail	756	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001064 transient receptor potential cation channel TRPV2

(term hierarchy)
PDB

7XEM, 7XEO, 7XER, 7XEU, 7XEV, 7XEW, 7YEP
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR005821 Ion transport domain

IPR024862 Transient receptor potential cation channel subfamily V

IPR008347 Transient receptor potential cation channel subfamily V member 1-4
GlyGen

Q9WTR1 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 40

cDNA 38

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 87

Developmental Gene Expression 13

Gene Ontology 9

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:353288 Li C, et al., Ion channel TRPV2 is critical in enhancing B cell activation and function. J Exp Med. 2024 Mar 4;221(3)

TSS for Trpv2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102038	Chr11:62465303-62465348 (+)	14 bp
Tssr102039	Chr11:62465349-62465378 (+)	52 bp
Tssr102040	Chr11:62465399-62465410 (+)	93 bp
Tssr102041	Chr11:62466444-62466468 (+)	1,144 bp
Tssr102042	Chr11:62466703-62466716 (+)	1,398 bp
Tssr102043	Chr11:62466723-62466759 (+)	1,429 bp
Tssr102044	Chr11:62466761-62466790 (+)	1,464 bp
Tssr102045	Chr11:62466807-62466818 (+)	1,501 bp
Tssr102046	Chr11:62466851-62466858 (+)	1,543 bp
Tssr102047	Chr11:62474724-62474747 (+)	9,424 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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