Ajuba MGI Mouse Gene Detail - MGI:1341886

Symbol

Ajuba
Name

ajuba LIM protein
Synonyms

Jub

Feature Type

protein coding gene
IDs

MGI:1341886
NCBI Gene: 16475
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:54804929-54815015 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 27.84 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

283 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341886	protein coding gene	Chr14:54804926-54815118 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021314	protein coding gene	Chr14:48526720-48538257 (-)
A/J	MGP_AJ_G0021273	protein coding gene	Chr14:47579155-47590070 (-)
AKR/J	MGP_AKRJ_G0021249	protein coding gene	Chr14:49291855-49301910 (-)
BALB/cJ	MGP_BALBcJ_G0021277	protein coding gene	Chr14:47551120-47562051 (-)
C3H/HeJ	MGP_C3HHeJ_G0021057	protein coding gene	Chr14:48992609-49002811 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021716	protein coding gene	Chr14:50993501-51004518 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019260	protein coding gene	Chr14:45993773-46004284 (-)
CAST/EiJ	MGP_CASTEiJ_G0020576	protein coding gene	Chr14:45232201-45242423 (-)
CBA/J	MGP_CBAJ_G0021024	protein coding gene	Chr14:52502532-52512660 (-)
DBA/2J	MGP_DBA2J_G0021145	protein coding gene	Chr14:47321073-47331137 (-)
FVB/NJ	MGP_FVBNJ_G0021127	protein coding gene	Chr14:46773840-46784093 (-)
LP/J	MGP_LPJ_G0021219	protein coding gene	Chr14:49533548-49543772 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021151	protein coding gene	Chr14:51924447-51935922 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021742	protein coding gene	Chr14:48484830-48495965 (-)
PWK/PhJ	MGP_PWKPhJ_G0020322	protein coding gene	Chr14:43848610-43859092 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020150	protein coding gene	Chr14:44468021-44478176 (-)
WSB/EiJ	MGP_WSBEiJ_G0020629	protein coding gene	Chr14:48778382-48788468 (-)

Human Ortholog

AJUBA, ajuba LIM protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AJUBA, ajuba LIM protein
Synonyms

JUB
Links

HGNC:20250

NCBI Gene ID: 84962

neXtProt AC: NX_Q96IF1

UniProt: Q96IF1
Chr Location

14q11.2; chr14:22971177-22982551 (-) GRCh38

MGI Vertebrate Homology

Ajuba stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AJUBA
Gene Tree

Ajuba

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

51
Chemically induced (other)

1
Endonuclease-mediated

9
Gene trapped

38
Targeted

3
Genomic Mutations

1 involving Ajuba
Incidental Mutations

APF
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one null allele are viable and reach adulthood without any obvious phenotypes; however, mouse embryonic fibroblasts exhibit impaired cell migration and abnormal lamellipodia production in vitro. Mice homozygous for a different null allele exhibit complete embryonic lethality.

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All GO Annotations

69
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

60
cDNA Data

31
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ajuba

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS27093.1

Ensembl

ENSMUSG00000022178 (Evidence)
NCBI Gene

16475

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022178	Ensembl Gene Model \| MGI Sequence Detail	10087	C57BL/6J	± kb
transcript	ENSMUST00000054487	Ensembl \| MGI Sequence Detail	3397	Not Applicable
polypeptide	ENSMUSP00000056977	Ensembl \| MGI Sequence Detail	547	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009231 protein ajuba

(term hierarchy)
InterPro Domains

IPR047172 Ajuba-like

IPR047245 Ajuba-like, LIM domain 1

IPR047247 Ajuba-like, LIM domain 2

IPR047248 Ajuba-like, LIM domain 3

IPR001781 Zinc finger, LIM-type
GlyGen

Q91XC0 1 site, 1 O-linked glycan (1 site)

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All nucleic 36

cDNA 32

Primer pair 4

Microarray probesets 2

Summaries

All 67

Developmental Gene Expression 13

Gene Ontology 17

Phenotypes 21
Earliest

J:55014 Goyal RK, et al., Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ajuba:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128606	Chr14:54815035-54815069 (-)	-37 bp
Tssr128605	Chr14:54815018-54815034 (-)	-11 bp
Tssr128604	Chr14:54815000-54815015 (-)	7 bp
Tssr128603	Chr14:54814984-54814996 (-)	25 bp
Tssr128602	Chr14:54814937-54814955 (-)	69 bp
Tssr128601	Chr14:54813123-54813165 (-)	1,871 bp
Tssr128600	Chr14:54810308-54810321 (-)	4,700 bp
Tssr128599	Chr14:54805671-54805714 (-)	9,322 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24