Uhmk1 MGI Mouse Gene Detail - MGI:1341908 - U2AF homology motif (UHM) kinase 1

Symbol

Uhmk1
Name

U2AF homology motif (UHM) kinase 1
Synonyms

C820018A03Rik, KIS, Kist, OTTMUSG00000021542

Feature Type

protein coding gene
IDs

MGI:1341908
NCBI Gene: 16589
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:170020989-170042966 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 76.84 cM, cytoband H2
Mapping Data

4 experiments

SNPs within 2kb

678 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341908	protein coding gene	Chr1:170020989-170043466 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016726	protein coding gene	Chr1:175884768-175906664 (-)
A/J	MGP_AJ_G0016706	protein coding gene	Chr1:168693269-168715308 (-)
AKR/J	MGP_AKRJ_G0016672	protein coding gene	Chr1:173776337-173798429 (-)
BALB/cJ	MGP_BALBcJ_G0016667	protein coding gene	Chr1:169194158-169216007 (-)
C3H/HeJ	MGP_C3HHeJ_G0016491	protein coding gene	Chr1:174026119-174048106 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017128	protein coding gene	Chr1:181714039-181736011 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014837	protein coding gene	Chr1:160448717-160470872 (-)
CAST/EiJ	MGP_CASTEiJ_G0016071	protein coding gene	Chr1:173657449-173679205 (-)
CBA/J	MGP_CBAJ_G0016466	protein coding gene	Chr1:188165106-188189665 (-)
DBA/2J	MGP_DBA2J_G0016572	protein coding gene	Chr1:167572326-167597750 (-)
FVB/NJ	MGP_FVBNJ_G0016570	protein coding gene	Chr1:165935555-165957777 (-)
LP/J	MGP_LPJ_G0016643	protein coding gene	Chr1:176940958-177044851 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016595	protein coding gene	Chr1:195506985-195529678 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017165	protein coding gene	Chr1:173667438-173689649 (-)
PWK/PhJ	MGP_PWKPhJ_G0015857	protein coding gene	Chr1:166805194-166827309 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015643	protein coding gene	Chr1:172420817-172442683 (-)
WSB/EiJ	MGP_WSBEiJ_G0016133	protein coding gene	Chr1:173785816-173809287 (-)

Human Ortholog

UHMK1, U2AF homology motif kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UHMK1, U2AF homology motif kinase 1
Synonyms

KIS, KIST, P-CIP2
Links

HGNC:19683

NCBI Gene ID: 127933

neXtProt AC: NX_Q8TAS1

UniProt: Q8TAS1
Chr Location

1q23.3; chr1:162497174-162529631 (+) GRCh38

MGI Vertebrate Homology

Uhmk1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UHMK1
Gene Tree

Uhmk1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

3
Targeted

1
Genomic Mutations

2 involving Uhmk1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with disruptions in this gene show accelerated development of neointima after arterial injury.

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All GO Annotations

65
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

53
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

54
RefSeq

8
UniProt

3
CCDS

CCDS15468.1, CCDS87917.1

Ensembl

ENSMUSG00000026667 (Evidence)
NCBI Gene

16589

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026667	Ensembl Gene Model \| MGI Sequence Detail	21978	C57BL/6J	± kb
transcript	ENSMUST00000027979	Ensembl \| MGI Sequence Detail	7864	Not Applicable
polypeptide	ENSMUSP00000027979	Ensembl \| MGI Sequence Detail	419	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017069 serine/threonine-protein kinase Kist

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034372 Serine/threonine-protein kinase Kist

IPR034371 UHMK1, RNA recognition motif

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 9

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MGI:2138124, MGI:2138247, MGI:2138467, MGI:3707359

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 9
Earliest

J:51752 Maucuer A, et al., Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3100-4
Latest

J:297898 Feng X, et al., UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. EMBO J. 2020 Mar 2;39(5):e102541

TSS for Uhmk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14915	Chr1:170042949-170042989 (-)	-3 bp
Tssr14914	Chr1:170039348-170039354 (-)	3,615 bp
Tssr14913	Chr1:170039337-170039344 (-)	3,625 bp
Tssr14912	Chr1:170039312-170039315 (-)	3,652 bp
Tssr14911	Chr1:170026336-170026360 (-)	16,618 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24