Slc25a17 MGI Mouse Gene Detail - MGI:1342248 - solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17

Symbol

Slc25a17
Name

solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
Synonyms

34kDa, PMP34

Feature Type

protein coding gene
IDs

MGI:1342248
NCBI Gene: 20524
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:81203122-81244966 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.05 cM
Mapping Data

1 experiment

SNPs within 2kb

1210 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1342248	protein coding gene	Chr15:81203112-81245013 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022109	protein coding gene	Chr15:81736386-81781420 (-)
A/J	MGP_AJ_G0022070	protein coding gene	Chr15:78866831-78908518 (-)
AKR/J	MGP_AKRJ_G0022045	protein coding gene	Chr15:81062388-81103896 (-)
BALB/cJ	MGP_BALBcJ_G0022076	protein coding gene	Chr15:78892310-78937537 (-)
C3H/HeJ	MGP_C3HHeJ_G0021847	protein coding gene	Chr15:81053826-81098654 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022519	protein coding gene	Chr15:84931970-84975460 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020049	protein coding gene	Chr15:75332283-75376250 (-)
CAST/EiJ	MGP_CASTEiJ_G0021368	protein coding gene	Chr15:81808494-81852697 (-)
CBA/J	MGP_CBAJ_G0021812	protein coding gene	Chr15:87584554-87631962 (-)
DBA/2J	MGP_DBA2J_G0021941	protein coding gene	Chr15:78349019-78391259 (-)
FVB/NJ	MGP_FVBNJ_G0021919	protein coding gene	Chr15:77388183-77431112 (-)
LP/J	MGP_LPJ_G0022009	protein coding gene	Chr15:81889706-81939588 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021939	protein coding gene	Chr15:92564085-92608574 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022533	protein coding gene	Chr15:81121575-81166821 (-)
PWK/PhJ	MGP_PWKPhJ_G0021110	protein coding gene	Chr15:78375741-78418784 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020947	protein coding gene	Chr15:80920691-80963352 (-)
WSB/EiJ	MGP_WSBEiJ_G0021420	protein coding gene	Chr15:81547924-81594557 (-)

Human Ortholog

SLC25A17, solute carrier family 25 member 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC25A17, solute carrier family 25 member 17
Synonyms

PMP34
Links

HGNC:10987

NCBI Gene ID: 10478

neXtProt AC: NX_O43808

UniProt: O43808
Chr Location

22q13.2; chr22:40769630-40819399 (-) GRCh38

MGI Vertebrate Homology

Slc25a17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC25A17
Gene Tree

Slc25a17

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 2 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

61
Chemically induced (other)

1
Gene trapped

56
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Slc25a17
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

71 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit background sensitive prenatal lethality and phytol-diet induced enlarged liver, hepatic steatosis, and liver apoptosis, and inflammation.

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All GO Annotations

43
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc25a17

ZFIN slc25a17

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All Sequences

57
RefSeq

2
UniProt

4
CCDS

CCDS27666.1

Ensembl

ENSMUSG00000022404 (Evidence)
NCBI Gene

20524

			Length	Strain/Species	Flank
genomic	20524	NCBI Gene Model \| MGI Sequence Detail	41845	C57BL/6J	± kb
transcript	NM_011399	RefSeq \| MGI Sequence Detail	1667	C57BL/6
polypeptide	O70579	UniProt \| EBI \| MGI Sequence Detail	307	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015012 peroxisomal membrane protein PMP34

(term hierarchy)
InterPro Domains

IPR052217 Mitochondrial and Peroxisomal Carrier Protein

IPR023395 Mitochondrial carrier domain superfamily

IPR002067 Mitochondrial carrier protein

IPR018108 Mitochondrial substrate/solute carrier

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 4

Summaries

All 57

Developmental Gene Expression 3

Diseases 1

Gene Ontology 8

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;

TSS for Slc25a17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135464	Chr15:81245032-81245054 (-)	-77 bp
Tssr135463	Chr15:81244940-81245017 (-)	-13 bp
Tssr135462	Chr15:81211503-81211529 (-)	33,450 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24