Gsto1 MGI Mouse Gene Detail - MGI:1342273 - glutathione S-transferase omega 1

Symbol

Gsto1
Name

glutathione S-transferase omega 1
Synonyms

GSTX, p28

Feature Type

protein coding gene
IDs

MGI:1342273
NCBI Gene: 14873
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr19:47843412-47853229 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 40.41 cM
Mapping Data

2 experiments

SNPs within 2kb

497 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1342273	protein coding gene	Chr19:47843409-47853229 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025235	protein coding gene	Chr19:47713019-47727109 (+)
A/J	MGP_AJ_G0025211	protein coding gene	Chr19:45314869-45324519 (+)
AKR/J	MGP_AKRJ_G0025180	protein coding gene	Chr19:46782235-46793206 (+)
BALB/cJ	MGP_BALBcJ_G0025206	protein coding gene	Chr19:45369990-45380734 (+)
C3H/HeJ	MGP_C3HHeJ_G0024966	protein coding gene	Chr19:46958741-46969798 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025649	protein coding gene	Chr19:48832591-48843212 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023062	protein coding gene	Chr19:44521387-44530681 (+)
CAST/EiJ	MGP_CASTEiJ_G0024431	protein coding gene	Chr19:46778229-46787827 (+)
CBA/J	MGP_CBAJ_G0024946	protein coding gene	Chr19:51311878-51322142 (+)
DBA/2J	MGP_DBA2J_G0025078	protein coding gene	Chr19:45133046-45142784 (+)
FVB/NJ	MGP_FVBNJ_G0025039	protein coding gene	Chr19:44904786-44914468 (+)
LP/J	MGP_LPJ_G0025164	protein coding gene	Chr19:47594314-47608838 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025070	protein coding gene	Chr19:50538472-50550038 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025707	protein coding gene	Chr19:46906440-46920043 (+)
PWK/PhJ	MGP_PWKPhJ_G0024180	protein coding gene	Chr19:45087223-45097489 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023983	protein coding gene	Chr19:45563429-45575809 (+)
WSB/EiJ	MGP_WSBEiJ_G0024501	protein coding gene	Chr19:47056179-47068510 (+)

Human Ortholog

GSTO1, glutathione S-transferase omega 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSTO1, glutathione S-transferase omega 1
Synonyms

GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R
Links

HGNC:13312

NCBI Gene ID: 9446

neXtProt AC: NX_P78417

UniProt: P78417
Chr Location

10q25.1; chr10:104235356-104267459 (+) GRCh38

MGI Vertebrate Homology

Gsto1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GSTO1
Gene Tree

Gsto1

Diseases

2 with human GSTO1 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a mutant allele do not display abnormal arsenate metabolism following acute arsenate exposure.

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All GO Annotations

33
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

860
Tissues

113
cDNA Data

154
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gsto1

ZFIN gsto1

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All Sequences

59
RefSeq

2
UniProt

3
CCDS

CCDS29893.1

Ensembl

ENSMUSG00000025068 (Evidence)
NCBI Gene

14873

			Length	Strain/Species	Flank
genomic	14873	NCBI Gene Model \| MGI Sequence Detail	9818	C57BL/6J	± kb
transcript	NM_010362	RefSeq \| MGI Sequence Detail	1192	C57BL/6
polypeptide	O09131	UniProt \| EBI \| MGI Sequence Detail	240	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008303 glutathione S-transferase omega-1

(term hierarchy)
EC

1.20.4.2, 1.8.5.1, 2.5.1.18
InterPro Domains

IPR004046 Glutathione S-transferase, C-terminal

IPR036282 Glutathione S-transferase, C-terminal domain superfamily

IPR010987 Glutathione S-transferase, C-terminal-like

IPR004045 Glutathione S-transferase, N-terminal

IPR005442 Glutathione S-transferase, omega-class

IPR050983 Glutathione S-transferase Omega/HSP26

IPR040079 Glutathione transferase family

IPR036249 Thioredoxin-like superfamily
GlyGen

O09131 1 site, 1 O-linked glycan (1 site)

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All nucleic 156

cDNA 154

Primer pair 1

Other 1

Microarray probesets 4

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MGI:2147425, MGI:2147485, MGI:2147644

Summaries

All 55

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 12
Earliest

J:53034 Kodym R, et al., The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins. J Biol Chem. 1999 Feb 19;274(8):5131-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gsto1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156889	Chr19:47842542-47842554 (+)	-864 bp
Tssr156890	Chr19:47842685-47842713 (+)	-713 bp
Tssr156891	Chr19:47843434-47843452 (+)	31 bp
Tssr156892	Chr19:47843457-47843460 (+)	47 bp
Tssr156893	Chr19:47843461-47843486 (+)	62 bp
Tssr156894	Chr19:47843646-47843664 (+)	243 bp
Tssr156895	Chr19:47846288-47846332 (+)	2,898 bp
Tssr156896	Chr19:47846430-47846446 (+)	3,026 bp
Tssr156897	Chr19:47847860-47847949 (+)	4,493 bp
Tssr156898	Chr19:47849176-47849187 (+)	5,770 bp
Tssr156899	Chr19:47849202-47849210 (+)	5,794 bp
Tssr156900	Chr19:47851814-47851825 (+)	8,408 bp
Tssr156901	Chr19:47851845-47851857 (+)	8,439 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24