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Slc25a15 Gene Detail
Summary
  • Symbol
    Slc25a15
  • Name
    solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15
  • Synonyms
    D630044L02Rik, Ornt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342274
    NCBI Gene: 18408
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22865567-22888613 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.26 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    801 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342274
 protein coding gene Chr8:22865566-22888637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033450
 protein coding gene Chr8:20223334-20246370 (-)
A/J MGP_AJ_G0033430
 protein coding gene Chr8:19566973-19590022 (-)
AKR/J MGP_AKRJ_G0033355
 protein coding gene Chr8:20201234-20225928 (-)
BALB/cJ MGP_BALBcJ_G0033426
 protein coding gene Chr8:19691931-19714961 (-)
C3H/HeJ MGP_C3HHeJ_G0033140
 protein coding gene Chr8:20406248-20429328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033942
 protein coding gene Chr8:21084665-21107720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030897
 protein coding gene Chr8:16893262-16918936 (-)
CAST/EiJ MGP_CASTEiJ_G0032466
 protein coding gene Chr8:19826292-19850812 (-)
CBA/J MGP_CBAJ_G0033115
 protein coding gene Chr8:21923275-21949282 (-)
DBA/2J MGP_DBA2J_G0033270
 protein coding gene Chr8:19536207-19559406 (-)
FVB/NJ MGP_FVBNJ_G0033214
 protein coding gene Chr8:19330419-19352872 (-)
LP/J MGP_LPJ_G0033359
 protein coding gene Chr8:20226780-20247388 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033257
 protein coding gene Chr8:21515756-21538796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033961
 protein coding gene Chr8:20108446-20131575 (-)
PWK/PhJ MGP_PWKPhJ_G0032178
 protein coding gene Chr8:19121842-19145055 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032011
 protein coding gene Chr8:19447103-19453875 (-)
WSB/EiJ MGP_WSBEiJ_G0032582
 protein coding gene Chr8:20318429-20341493 (-)



Homology
more
  • Human Ortholog
    SLC25A15, solute carrier family 25 member 15
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A15, solute carrier family 25 member 15
  • Synonyms
    D13S327, HHH, LNC-HC, ORC1, ORNT1
  • Links
    NCBI Gene ID: 10166
    neXtProt AC: NX_Q9Y619
    UniProt: Q9Y619

  • Chr Location
    13q14.11; chr13:40789412-40812460 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SLC25A15 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    4
  • cDNA Data
    53
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031482 Ensembl Gene Model | MGI Sequence Detail 23047 C57BL/6J ±  kb
    transcript ENSMUST00000033871 Ensembl | MGI Sequence Detail 3430 Not Applicable  
    polypeptide ENSMUSP00000033871 Ensembl | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 53
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444400
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:55475 Camacho JA, et al., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Nat Genet. 1999 Jun;22(2):151-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory