Unc13b MGI Mouse Gene Detail - MGI:1342278

Symbol

Unc13b
Name

unc-13 homolog B
Synonyms

Munc13-2, Unc13h2

Feature Type

protein coding gene
IDs

MGI:1342278
NCBI Gene: 22249
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr4:43058953-43264871 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 23.00 cM, cytoband B1
Mapping Data

1 experiment

SNPs within 2kb

5250 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1342278	protein coding gene	Chr4:43046193-43264873 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028201	protein coding gene	Chr4:41141722-41362888 (+)
A/J	MGP_AJ_G0028157	protein coding gene	Chr4:39699319-39903316 (+)
AKR/J	MGP_AKRJ_G0028109	protein coding gene	Chr4:40606454-40811612 (+)
BALB/cJ	MGP_BALBcJ_G0028177	protein coding gene	Chr4:39792010-39994240 (+)
C3H/HeJ	MGP_C3HHeJ_G0027899	protein coding gene	Chr4:41230005-41431203 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028618	protein coding gene	Chr4:42676497-42891060 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025930	protein coding gene	Chr4:37164526-37353736 (+)
CAST/EiJ	MGP_CASTEiJ_G0027339	protein coding gene	Chr4:40706932-40932554 (+)
CBA/J	MGP_CBAJ_G0027865	protein coding gene	Chr4:44017571-44226810 (+)
DBA/2J	MGP_DBA2J_G0028014	protein coding gene	Chr4:39614509-39817657 (+)
FVB/NJ	MGP_FVBNJ_G0027981	protein coding gene	Chr4:38837205-39034816 (+)
LP/J	MGP_LPJ_G0028113	protein coding gene	Chr4:41208490-41420075 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028005	protein coding gene	Chr4:47287848-47500034 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028654	protein coding gene	Chr4:40799134-41004163 (+)
PWK/PhJ	MGP_PWKPhJ_G0027065	protein coding gene	Chr4:39649147-39849572 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026891	protein coding gene	Chr4:40351567-40562910 (+)
WSB/EiJ	MGP_WSBEiJ_G0027419	protein coding gene	Chr4:40704926-40907580 (+)

Human Ortholog

UNC13B, unc-13 homolog B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNC13B, unc-13 homolog B
Synonyms

MUNC13, munc13-2, UNC13, Unc13h2
Links

HGNC:12566

NCBI Gene ID: 10497

neXtProt AC: NX_O14795

UniProt: O14795
Chr Location

9p13.3; chr9:35161992-35405338 (+) GRCh38

MGI Vertebrate Homology

Unc13b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UNC13B
Gene Tree

Unc13b

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically and radiation induced

1
Targeted

5
Genomic Mutations

1 involving Unc13b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

119 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice are grossly phenotypically normal. Mice older than 12 months will exhibit sporadic seizures.

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All GO Annotations

75
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

820
Tissues

61
cDNA Data

92
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase unc13b

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All Sequences

120
RefSeq

46
UniProt

7
CCDS

CCDS38738.1, CCDS51161.1, CCDS80089.1

Ensembl

ENSMUSG00000028456 (Evidence)
NCBI Gene

22249

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028456	Ensembl Gene Model \| MGI Sequence Detail	205919	C57BL/6J	± kb
transcript	ENSMUST00000207569	Ensembl \| MGI Sequence Detail	14754	Not Applicable
polypeptide	ENSMUSP00000147100	Ensembl \| MGI Sequence Detail	4390	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000017087 protein unc-13 homolog B

(term hierarchy)
InterPro Domains

IPR046349 C1-like domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR014772 Mammalian uncoordinated homology 13, domain 2

IPR014770 Munc13 homology 1

IPR010439 MUN domain

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR027080 Protein Unc-13

IPR037302 Protein Unc-13, C2B domain

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All nucleic 94

Genomic 1

cDNA 93

Microarray probesets 3

Summaries

All 90

Developmental Gene Expression 5

Gene Ontology 18

Phenotypes 47
Earliest

J:56513 Augustin I, et al., Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature. 1999 Jul 29;400(6743):457-61
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Unc13b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36921	Chr4:43058939-43058962 (+)	-2 bp
Tssr36922	Chr4:43058976-43059011 (+)	41 bp
Tssr36923	Chr4:43059028-43059045 (+)	84 bp
Tssr36924	Chr4:43135814-43135818 (+)	76,863 bp
Tssr36925	Chr4:43209224-43209275 (+)	150,297 bp
Tssr36926	Chr4:43209286-43209309 (+)	150,345 bp
Tssr36927	Chr4:43249443-43249500 (+)	190,519 bp
Tssr36928	Chr4:43249574-43249600 (+)	190,634 bp
Tssr36929	Chr4:43257768-43257777 (+)	198,820 bp
Tssr36930	Chr4:43257861-43257875 (+)	198,915 bp
Tssr36931	Chr4:43264249-43264256 (+)	205,300 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24