Flii MGI Mouse Gene Detail - MGI:1342286 - flightless I actin binding protein

Symbol

Flii
Name

flightless I actin binding protein
Synonyms

3632430F08Rik, Fliih

Feature Type

protein coding gene
IDs

MGI:1342286
NCBI Gene: 14248
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:60604969-60618089 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.81 cM, cytoband B
Mapping Data

4 experiments

SNPs within 2kb

369 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1342286	protein coding gene	Chr11:60604949-60618089 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018422	protein coding gene	Chr11:60628601-60641739 (-)
A/J	MGP_AJ_G0018391	protein coding gene	Chr11:58397112-58410246 (-)
AKR/J	MGP_AKRJ_G0018361	protein coding gene	Chr11:60250625-60263826 (-)
BALB/cJ	MGP_BALBcJ_G0018362	protein coding gene	Chr11:58694084-58707224 (-)
C3H/HeJ	MGP_C3HHeJ_G0018175	protein coding gene	Chr11:60185100-60198242 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018814	protein coding gene	Chr11:62549602-62562742 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016460	protein coding gene	Chr11:55539760-55553481 (-)
CAST/EiJ	MGP_CASTEiJ_G0017732	protein coding gene	Chr11:60282330-60295659 (-)
CBA/J	MGP_CBAJ_G0018149	protein coding gene	Chr11:65270410-65285961 (-)
DBA/2J	MGP_DBA2J_G0018258	protein coding gene	Chr11:57983644-57996779 (-)
FVB/NJ	MGP_FVBNJ_G0018249	protein coding gene	Chr11:57645879-57658996 (-)
LP/J	MGP_LPJ_G0018331	protein coding gene	Chr11:61206812-61221175 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018273	protein coding gene	Chr11:66328424-66341563 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018855	protein coding gene	Chr11:60341237-60354366 (-)
PWK/PhJ	MGP_PWKPhJ_G0017505	protein coding gene	Chr11:58561222-58574295 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017295	protein coding gene	Chr11:60159814-60172980 (-)
WSB/EiJ	MGP_WSBEiJ_G0017784	protein coding gene	Chr11:59963271-59976384 (-)

Human Ortholog

FLII, FLII actin remodeling protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLII, FLII actin remodeling protein
Synonyms

CMD2J, FLI, Fli1, FLIL
Links

HGNC:3750

NCBI Gene ID: 2314

neXtProt AC: NX_Q13045

UniProt: Q13045
Chr Location

17p11.2; chr17:18244815-18259022 (-) GRCh38

MGI Vertebrate Homology

Flii stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FLII
Gene Tree

Flii

Diseases

1 with human FLII associations

				Human Disease	Mouse Models
				dilated cardiomyopathy IDs dilated cardiomyopathy DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193

Click on a disease name to see all genes associated with that disease.

References

2 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

8
Genomic Mutations

3 involving Flii
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available

Embryos homozygous for a knock-out allele are able to initiate uterine implantation but degenerate rapidly thereafter. Heterozygous mutant mice display enhanced wound healing with increased epithelial migration and improved wound contraction.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

43
cDNA Data

198
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase flii

ZFIN flii

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All Sequences

51
RefSeq

4
UniProt

2
CCDS

CCDS24795.1

Ensembl

ENSMUSG00000002812 (Evidence)
NCBI Gene

14248

			Length	Strain/Species	Flank
genomic	14248	NCBI Gene Model \| MGI Sequence Detail	13121	C57BL/6J	± kb
transcript	NM_022009	RefSeq \| MGI Sequence Detail	4071	ZRU/MplStud
polypeptide	Q9JJ28	UniProt \| EBI \| MGI Sequence Detail	1271	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007554 protein flightless-1

(term hierarchy)
InterPro Domains

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR007123 Gelsolin-like domain

IPR036180 Gelsolin-like domain superfamily

IPR001611 Leucine-rich repeat

IPR025875 Leucine rich repeat 4

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR007122 Villin/Gelsolin
GlyGen

Q9JJ28 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 198

cDNA 198

Microarray probesets 5

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MGI:1921278

Summaries

All 82

Developmental Gene Expression 4

Diseases 2

Gene Ontology 12

Phenotypes 35
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Flii:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108302	Chr11:60618096-60618097 (-)	-8 bp
Tssr108301	Chr11:60618083-60618094 (-)	0 bp
Tssr108300	Chr11:60618078-60618081 (-)	9 bp
Tssr108299	Chr11:60618022-60618077 (-)	39 bp
Tssr108298	Chr11:60614239-60614260 (-)	3,839 bp
Tssr108297	Chr11:60613477-60613504 (-)	4,598 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24