Rps6ka2 MGI Mouse Gene Detail - MGI:1342290 - ribosomal protein S6 kinase, polypeptide 2

Symbol

Rps6ka2
Name

ribosomal protein S6 kinase, polypeptide 2
Synonyms

90kDa, D17Wsu134e, p90rsk, pp90rsk, Rps6ka-rs1, Rsk3

Feature Type

protein coding gene
IDs

MGI:1342290
NCBI Gene: 20112
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:7356384-7570714 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 4.70 cM, cytoband F4
Mapping Data

7 experiments

SNPs within 2kb

4241 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1342290	protein coding gene	Chr17:7292942-7570726 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023118	protein coding gene	Chr17:4423916-4566534 (+)
A/J	MGP_AJ_G0023092	protein coding gene	Chr17:4652073-4840899 (+)
AKR/J	MGP_AKRJ_G0023057	protein coding gene	Chr17:4947723-5094114 (-)
BALB/cJ	MGP_BALBcJ_G0023093	protein coding gene	Chr17:4476588-4618022 (+)
C3H/HeJ	MGP_C3HHeJ_G0022854	protein coding gene	Chr17:4590136-4727598 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023533	protein coding gene	Chr17:4690360-4834403 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021070	protein coding gene	Chr17:8899671-9037487 (+)
CAST/EiJ	MGP_CASTEiJ_G0022365	protein coding gene	Chr17:4372668-4523276 (+)
CBA/J	MGP_CBAJ_G0022818	protein coding gene	Chr17:4890187-5039346 (+)
DBA/2J	MGP_DBA2J_G0022960	protein coding gene	Chr17:4373562-4509833 (+)
FVB/NJ	MGP_FVBNJ_G0022929	protein coding gene	Chr17:4280122-4422051 (+)
LP/J	MGP_LPJ_G0023031	protein coding gene	Chr17:5038082-5186177 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022948	protein coding gene	Chr17:4812686-4950040 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023559	protein coding gene	Chr17:4521880-4668421 (+)
PWK/PhJ	MGP_PWKPhJ_G0022112	protein coding gene	Chr17:3933128-4080241 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021947	protein coding gene	Chr17:4505921-4651886 (-)
WSB/EiJ	no annotation

Human Ortholog

RPS6KA2, ribosomal protein S6 kinase A2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS6KA2, ribosomal protein S6 kinase A2
Synonyms

HU-2, MAPKAPK1C, p90RSK2, p90-RSK3, pp90RSK3, RSK, RSK3, S6K-alpha, S6K-alpha2
Links

HGNC:10431

NCBI Gene ID: 6196

neXtProt AC: NX_Q15349

UniProt: Q15349
Chr Location

6q27; chr6:166409364-166906451 (-) GRCh38

MGI Vertebrate Homology

Rps6ka2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS6KA2
Gene Tree

Rps6ka2

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References

6 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
360 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

7
Radiation induced

1
Targeted

1
Genomic Mutations

1 involving Rps6ka2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased response of heart to stress following transverse aortic constriction.

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All GO Annotations

57
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

161
cDNA Data

19
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

69
RefSeq

10
UniProt

8
CCDS

CCDS28376.1

Ensembl

ENSMUSG00000023809 (Evidence)
NCBI Gene

20112

			Length	Strain/Species	Flank
genomic	20112	NCBI Gene Model \| MGI Sequence Detail	214331	C57BL/6J	± kb
transcript	NM_011299	RefSeq \| MGI Sequence Detail	5394	ZRU/MplStud
polypeptide	Q9WUT3	UniProt \| EBI \| MGI Sequence Detail	733	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014283 ribosomal protein S6 kinase alpha-2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR017441 Protein kinase, ATP binding site

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016239 Ribosomal protein S6 kinase II

IPR041906 Ribosomal S6 kinase, N-terminal catalytic domain

IPR042766 RSK3, C-terminal catalytic domain

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 23

cDNA 19

Primer pair 4

Microarray probesets 5

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MGD-MRK-35693, MGI:107228, MGI:1098261

Summaries

All 423

Developmental Gene Expression 18

Diseases 6

Gene Ontology 13

Phenotypes 360
Earliest

J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
Latest

J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170

TSS for Rps6ka2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142488	Chr17:7405837-7405850 (+)	49,460 bp
Tssr142489	Chr17:7405862-7405882 (+)	49,488 bp
Tssr142490	Chr17:7405894-7405901 (+)	49,514 bp
Tssr142491	Chr17:7437484-7437496 (+)	81,106 bp
Tssr142492	Chr17:7437500-7437531 (+)	81,132 bp
Tssr142493	Chr17:7437536-7437562 (+)	81,165 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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