Rbmx MGI Mouse Gene Detail - MGI:1343044 - RNA binding motif protein, X chromosome

Symbol

Rbmx
Name

RNA binding motif protein, X chromosome

Feature Type

protein coding gene
IDs

MGI:1343044
NCBI Gene: 19655
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

ChrX:56428890-56438396 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 31.64 cM
Mapping Data

3 experiments

SNPs within 2kb

224 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1343044	protein coding gene	ChrX:56428708-56438405 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035748	protein coding gene	ChrX:52717592-52727103 (-)
A/J	MGP_AJ_G0035731	protein coding gene	ChrX:52913145-52923191 (-)
AKR/J	MGP_AKRJ_G0035651	protein coding gene	ChrX:54312514-54321822 (-)
BALB/cJ	MGP_BALBcJ_G0035718	protein coding gene	ChrX:52353601-52363103 (-)
C3H/HeJ	MGP_C3HHeJ_G0035420	protein coding gene	ChrX:53250889-53260398 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036247	protein coding gene	ChrX:54103510-54113921 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033098	protein coding gene	ChrX:52308000-52317687 (-)
CAST/EiJ	MGP_CASTEiJ_G0034713	protein coding gene	ChrX:39139487-39148998 (-)
CBA/J	MGP_CBAJ_G0035395	protein coding gene	ChrX:55692291-55701793 (-)
DBA/2J	MGP_DBA2J_G0035549	protein coding gene	ChrX:52482499-52492003 (-)
FVB/NJ	MGP_FVBNJ_G0035499	protein coding gene	ChrX:52081585-52091491 (-)
LP/J	MGP_LPJ_G0035637	protein coding gene	ChrX:53296116-53307126 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035535	protein coding gene	ChrX:57235312-57244833 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036263	protein coding gene	ChrX:52740453-52749955 (-)
PWK/PhJ	MGP_PWKPhJ_G0034409	protein coding gene	ChrX:37402744-37412300 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034253	protein coding gene	ChrX:39892751-39902319 (-)
WSB/EiJ	MGP_WSBEiJ_G0034856	protein coding gene	ChrX:52283417-52292925 (-)

Human Ortholog

RBMX, RNA binding motif protein X-linked

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBMX, RNA binding motif protein X-linked
Synonyms

hnRNP-G, HNRNPG, HNRPG, MRXS11, MRXSG, MRXSH, RBMXP1, RBMXRT, RNMX
Links

HGNC:9910

NCBI Gene ID: 27316

neXtProt AC: NX_P38159

UniProt: P38159
Chr Location

Xq26.3; chrX:136848004-136880764 (-) GRCh38

MGI Vertebrate Homology

Rbmx stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBMX
Gene Tree

Rbmx

Diseases

2 with human RBMX associations

				Human Disease	Mouse Models
				syndromic X-linked intellectual disability Shashi type IDs syndromic X-linked intellectual disability Shashi type DOID:0060826 ICD10CM:Q87.8 OMIM:300238 ORDO:85286
				X-linked mental retardation Gustavson type IDs X-linked mental retardation Gustavson type DOID:0081123 OMIM:309555 ORDO:3078

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

3
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

42
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

58
cDNA Data

150
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbmx

ZFIN rbmx

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All Sequences

79
RefSeq

17
UniProt

4
CCDS

CCDS30153.1

Ensembl

ENSMUSG00000031134 (Evidence)
NCBI Gene

19655

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031134	Ensembl Gene Model \| MGI Sequence Detail	9507	C57BL/6J	± kb
transcript	ENSMUST00000114730	Ensembl \| MGI Sequence Detail	2019	Not Applicable
polypeptide	ENSMUSP00000110378	Ensembl \| MGI Sequence Detail	391	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013813 RNA-binding motif protein, X chromosome

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR012604 RBM1CTR

IPR035979 RNA-binding domain superfamily

IPR050441 RNA-binding motif

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote
GlyGen

Q9WV02 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 151

cDNA 150

Primer pair 1

Microarray probesets 10

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 14
Earliest

J:55846 Mazeyrat S, et al., RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene [letter]. Nat Genet. 1999 Jul;22(3):224-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rbmx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163455	ChrX:56438389-56438400 (-)	1 bp
Tssr163454	ChrX:56438331-56438348 (-)	56 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24