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Robo3 Gene Detail
Summary
  • Symbol
    Robo3
  • Name
    roundabout guidance receptor 3
  • Synonyms
    Rbig1, Rig-1, Rig1, Robo3a, Robo3b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343102
    NCBI Gene: 19649
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37327341-37344730 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.76 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    430 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343102
 protein coding gene Chr9:37326965-37344730 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034564
 protein coding gene Chr9:35391375-35419625 (-)
A/J MGP_AJ_G0034543
 protein coding gene Chr9:34455103-34472893 (-)
AKR/J MGP_AKRJ_G0034470
 protein coding gene Chr9:35217902-35235376 (-)
BALB/cJ MGP_BALBcJ_G0034534
 protein coding gene Chr9:34299888-34317641 (-)
C3H/HeJ MGP_C3HHeJ_G0034247
 protein coding gene Chr9:35650188-35667661 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035056
 protein coding gene Chr9:36520474-36552126 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031982
 protein coding gene Chr9:33571650-33589060 (-)
CAST/EiJ MGP_CASTEiJ_G0033568
 protein coding gene Chr9:35341852-35359146 (-)
CBA/J MGP_CBAJ_G0034220
 protein coding gene Chr9:37786135-37805341 (-)
DBA/2J MGP_DBA2J_G0034378
 protein coding gene Chr9:34511821-34529322 (-)
FVB/NJ MGP_FVBNJ_G0034319
 protein coding gene Chr9:33754722-33772223 (-)
LP/J MGP_LPJ_G0034463
 protein coding gene Chr9:35592283-35609789 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034365
 protein coding gene Chr9:39401651-39419117 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035075
 protein coding gene Chr9:35153749-35171234 (-)
PWK/PhJ MGP_PWKPhJ_G0033274
 protein coding gene Chr9:34407695-34425398 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033108
 protein coding gene Chr9:35354846-35372077 (-)
WSB/EiJ MGP_WSBEiJ_G0033684
 protein coding gene Chr9:34959573-34976820 (-)



Homology
more
  • Human Ortholog
    ROBO3, roundabout guidance receptor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROBO3, roundabout guidance receptor 3
  • Synonyms
    HGPPS, HGPPS1, HGPS, RBIG1, RIG1
  • Links
    NCBI Gene ID: 64221
    neXtProt AC: NX_Q96MS0
    UniProt: Q96MS0

  • Chr Location
    11q24.2; chr11:124865432-124881471 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 10 genetic backgrounds
    2 phenotypes from multigenic genotypes
    7 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display perinatal lethality, abnormal commissural axon growth, and fragile floor plates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1287
  • Tissues
    226
  • cDNA Data
    16
  • Literature Summary
    116
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19649 NCBI Gene Model | MGI Sequence Detail 17390 C57BL/6J ±  kb
    transcript NM_001164767 RefSeq | MGI Sequence Detail 4726 C57BL/6  
    polypeptide Q9Z2I4 UniProt | EBI | MGI Sequence Detail 1402 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 2
      cDNA 20
      Primer pair 6
      Other 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 116
      Gene Ontology 11
      Phenotypes 43
    • Earliest
      J:53337 Yuan SS, et al., Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999 Mar 1;207(1):62-75
    • Latest
      J:358320 Hochbaum DR, et al., Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration. Cell. 2024 Oct 3;187(20):5679-5697.e23
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory