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Ccl27a Gene Detail
Summary
  • Symbol
    Ccl27a
  • Name
    C-C motif chemokine ligand 27A
  • Synonyms
    ALP, Ccl27, CTACK, CTAK, ESkine, ESkine, ILC, mILC, PESKY, Scya27, Scya27a, skinskine
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343459
    NCBI Gene: 20301
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41769467-41774247 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343459
 protein coding gene Chr4:41769467-41774251 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0028134
 protein coding gene Chr4:38226465-38236990 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0028146
 protein coding gene Chr4:38569208-38576748 (-)
C3H/HeJ MGP_C3HHeJ_G0027868
 protein coding gene Chr4:39698993-39708669 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0027845
 protein coding gene Chr4:42604240-42609019 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0027956
 protein coding gene Chr4:37474237-37476317 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0027048
 protein coding gene Chr4:38195720-38210610 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CCL27, C-C motif chemokine ligand 27
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL27, C-C motif chemokine ligand 27
  • Synonyms
    ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27
  • Links
    NCBI Gene ID: 10850
    neXtProt AC: NX_Q9Y4X3
    UniProt: Q9Y4X3

  • Chr Location
    9p13.3; chr9:34661880-34664048 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically and radiation induced
    1
  • Endonuclease-mediated
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Ccl27a
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    13 strains or lines available
Mice homozygous for a Ccl27a knock-out allele show only a slight alteration in the establishment of CCR10+ skin-resident lymphocytes. Mice with all Ccl27 genes knocked-out show impaired migration and localization of CCR10+ lymphocytes into skin, increased susceptibility to imiquimod-induced skin inflammation, increased infiltration of CCR10+ T cells into lungs and female reproductive tracts, and uterus inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    49
  • cDNA Data
    16
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073888 Ensembl Gene Model | MGI Sequence Detail 4781 C57BL/6J ±  kb
transcript ENSMUST00000108037 Ensembl | MGI Sequence Detail 590 Not Applicable  
polypeptide ENSMUSP00000103672 Ensembl | MGI Sequence Detail 164 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 7
Other
Accession IDs
less
MGI:1891388, MGI:2140607
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:27000 Forger JM 3rd, et al., Murine infection by vesicular stomatitis virus: initial characterization of the H-2d system. J Virol. 1991 Sep;65(9):4950-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory