Commd8 MGI Mouse Gene Detail - MGI:1343485

Symbol

Commd8
Name

COMM domain containing 8
Synonyms

D5Buc26e, IMAGE:1958590

Feature Type

protein coding gene
IDs

MGI:1343485
NCBI Gene: 27784
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:72313919-72325532 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 38.44 cM
Mapping Data

3 experiments

SNPs within 2kb

610 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1343485	protein coding gene	Chr5:72313918-72325532 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029610	protein coding gene	Chr5:72060176-72071805 (-)
A/J	MGP_AJ_G0029578	protein coding gene	Chr5:69369474-69381081 (-)
AKR/J	MGP_AKRJ_G0029526	protein coding gene	Chr5:71576189-71587795 (-)
BALB/cJ	MGP_BALBcJ_G0029587	protein coding gene	Chr5:70036189-70047801 (-)
C3H/HeJ	MGP_C3HHeJ_G0029310	protein coding gene	Chr5:71948527-71960132 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030041	protein coding gene	Chr5:75051551-75063167 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027281	protein coding gene	Chr5:65097360-65109726 (-)
CAST/EiJ	MGP_CASTEiJ_G0028718	protein coding gene	Chr5:71072301-71083972 (-)
CBA/J	MGP_CBAJ_G0029279	protein coding gene	Chr5:77442247-77453859 (-)
DBA/2J	MGP_DBA2J_G0029425	protein coding gene	Chr5:69427750-69439354 (-)
FVB/NJ	MGP_FVBNJ_G0029385	protein coding gene	Chr5:68608072-68619680 (-)
LP/J	MGP_LPJ_G0029510	protein coding gene	Chr5:72545222-72556840 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029413	protein coding gene	Chr5:80841786-80854437 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030074	protein coding gene	Chr5:71174696-71186316 (-)
PWK/PhJ	MGP_PWKPhJ_G0028442	protein coding gene	Chr5:68389191-68401096 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028276	protein coding gene	Chr5:70541320-70553352 (-)
WSB/EiJ	MGP_WSBEiJ_G0028798	protein coding gene	Chr5:71418562-71430342 (-)

Human Ortholog

COMMD8, COMM domain containing 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COMMD8, COMM domain containing 8
Links

HGNC:26036

NCBI Gene ID: 54951

neXtProt AC: NX_Q9NX08

UniProt: Q9NX08
Chr Location

4p12; chr4:47450787-47463702 (-) GRCh38

MGI Vertebrate Homology

Commd8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COMMD8
Gene Tree

Commd8

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Commd8
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in B cells exhibit impaired B cell migration and humoral immune responses.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

85

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase commd8

ZFIN commd8

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All Sequences

69
RefSeq

14
UniProt

5
CCDS

CCDS39108.1

Ensembl

ENSMUSG00000029213 (Evidence)
NCBI Gene

27784

			Length	Strain/Species	Flank
genomic	27784	NCBI Gene Model \| MGI Sequence Detail	11614	C57BL/6J	± kb
transcript	NM_001356614	RefSeq \| MGI Sequence Detail	4110	ZRU/MplStud
polypeptide	Q9CZG3	UniProt \| EBI \| MGI Sequence Detail	183	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000032386 COMM domain-containing protein 8

(term hierarchy)
InterPro Domains

IPR017920 COMM domain

IPR047155 COMM domain-containing protein 4/6/7/8

IPR047235 COMM domain-containing protein 8

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All nucleic 94

Genomic 8

cDNA 85

Primer pair 1

Microarray probesets 4

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MGI:2141294

Summaries

All 44

Gene Ontology 3

Phenotypes 18
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:337427 Shirai T, et al., Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. Sci Immunol. 2023 Mar 31;8(81):eadc9324

TSS for Commd8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51292	Chr5:72325485-72325542 (-)	18 bp
Tssr51291	Chr5:72325461-72325481 (-)	61 bp
Tssr51290	Chr5:72322477-72322481 (-)	3,053 bp
Tssr51289	Chr5:72320404-72320419 (-)	5,120 bp
Tssr51288	Chr5:72317129-72317144 (-)	8,395 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24