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Rpl10a Gene Detail
Summary
  • Symbol
    Rpl10a
  • Name
    ribosomal protein L10A
  • Synonyms
    CsA-19, Nedd6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343877
    NCBI Gene: 19896
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28547557-28550007 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343877
 protein coding gene Chr17:28547445-28550007 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023438
 protein coding gene Chr17:27716985-27719667 (+)
A/J MGP_AJ_G0023396
 protein coding gene Chr17:26809994-26812556 (+)
AKR/J MGP_AKRJ_G0023361
 protein coding gene Chr17:27006402-27010850 (+)
BALB/cJ MGP_BALBcJ_G0023401
 protein coding gene Chr17:27076922-27079522 (+)
C3H/HeJ MGP_C3HHeJ_G0023162
 protein coding gene Chr17:27388372-27390961 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023843
 protein coding gene Chr17:28835462-28839847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021318
 protein coding gene Chr17:24182433-24184860 (+)
CAST/EiJ MGP_CASTEiJ_G0022663
 protein coding gene Chr17:27367702-27372330 (+)
CBA/J MGP_CBAJ_G0023136
 protein coding gene Chr17:29861398-29867415 (+)
DBA/2J MGP_DBA2J_G0023267
 protein coding gene Chr17:26364116-26366674 (+)
FVB/NJ MGP_FVBNJ_G0023237
 protein coding gene Chr17:26172816-26175448 (+)
LP/J MGP_LPJ_G0023345
 protein coding gene Chr17:27969919-27974258 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023255
 protein coding gene Chr17:29297406-29305431 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023885
 protein coding gene Chr17:27425988-27431531 (+)
PWK/PhJ MGP_PWKPhJ_G0022413
 protein coding gene Chr17:25172284-25175125 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022231
 protein coding gene Chr17:25434130-25437396 (+)
WSB/EiJ MGP_WSBEiJ_G0022725
 protein coding gene Chr17:27425636-27429352 (+)



Homology
more
  • Human Ortholog
    RPL10A, ribosomal protein L10a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL10A, ribosomal protein L10a
  • Synonyms
    Csa-19, CSA19, L10A, NEDD6, uL1
  • Links
    NCBI Gene ID: 4736
    neXtProt AC: NX_P62906
    UniProt: P62906

  • Chr Location
    6p21.31; chr6:35468401-35470785 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality prior to E9.5. Mice homozygous for a hypomorphic allele exhibit perinatal lethality, abnormal brain morphology, edema, ectopic blood vessels, caudal body truncation, short rostral-caudal axis, abnormal somites, oligodactyly, and altered respiratory cilium basal feet orientation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    21
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19896 NCBI Gene Model | MGI Sequence Detail 2451 C57BL/6J ±  kb
    transcript NM_001357628 RefSeq | MGI Sequence Detail 951 C57BL/6  
    polypeptide P53026 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000014188 eukaryotic-type large ribosomal subunit protein uL1
      (term hierarchy)
    • PDB
      7LS1, 7LS2
    • InterPro Domains
      IPR050257 Eukaryotic ribosomal RNA-processing and assembly protein
      IPR002143 Large ribosomal subunit protein uL1
      IPR016095 Large ribosomal subunit protein uL1, 3-layer alpha/beta-sandwich domain
      IPR023673 Large ribosomal subunit protein uL1, conserved site
      IPR023674 Ribosomal protein uL1-like
      IPR028364 Ribosomal protein uL1/ribosomal biogenesis protein
    • GlyGen
      P53026 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12812, MGI:97299
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
    • Latest
      J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory