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Tiam2 Gene Detail
Summary
  • Symbol
    Tiam2
  • Name
    T cell lymphoma invasion and metastasis 2
  • Synonyms
    3000002F19Rik, mKIAA2016, STEF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344338
    NCBI Gene: 24001
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:3376675-3569672 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 1.99 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6071 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344338
 protein coding gene Chr17:3376675-3581619 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023098
 protein coding gene Chr17:292280-494389 (+)
A/J MGP_AJ_G0023069
 protein coding gene Chr17:399534-601401 (+)
AKR/J MGP_AKRJ_G0023035
 protein coding gene Chr17:325326-529438 (+)
BALB/cJ MGP_BALBcJ_G0023071
 protein coding gene Chr17:318773-514465 (+)
C3H/HeJ MGP_C3HHeJ_G0022830
 protein coding gene Chr17:391861-606752 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023517
 protein coding gene Chr17:438447-641976 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021017
 protein coding gene Chr17:235853-427663 (+)
CAST/EiJ MGP_CASTEiJ_G0022349
 protein coding gene Chr17:380307-591021 (+)
CBA/J MGP_CBAJ_G0022798
 protein coding gene Chr17:393342-612913 (+)
DBA/2J MGP_DBA2J_G0022933
 protein coding gene Chr17:261400-455652 (+)
FVB/NJ MGP_FVBNJ_G0022907
 protein coding gene Chr17:282571-480367 (+)
LP/J MGP_LPJ_G0023002
 protein coding gene Chr17:434480-640278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022928
 protein coding gene Chr17:343412-569167 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023534
 protein coding gene Chr17:306940-519252 (+)
PWK/PhJ MGP_PWKPhJ_G0022094
 protein coding gene Chr17:297866-496288 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021922
 protein coding gene Chr17:266807-471838 (+)
WSB/EiJ MGP_WSBEiJ_G0022400
 protein coding gene Chr17:320529-525475 (+)



Homology
more
  • Human Ortholog
    TIAM2, TIAM Rac1 associated GEF 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIAM2, TIAM Rac1 associated GEF 2
  • Synonyms
    STEF, TIAM-2
  • Links
    NCBI Gene ID: 26230
    neXtProt AC: NX_Q8IVF5
    UniProt: Q8IVF5

  • Chr Location
    6q25.2-q25.3; chr6:154832697-155257723 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
Mcie heterozygous for a knock-out allele exhibit reduced transmission of the t-haplotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    75
  • cDNA Data
    17
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24001 NCBI Gene Model | MGI Sequence Detail 192998 C57BL/6J ±  kb
transcript NM_001122998 RefSeq | MGI Sequence Detail 6144 ZRU/MplStud  
polypeptide Q6ZPF3 UniProt | EBI | MGI Sequence Detail 1715 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 18
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2447820
References
more
  • Summaries
    All 48
    Developmental Gene Expression 13
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:50543 Kawasaki H, et al., A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia [published erratum appears in Proc Natl Acad Sci U S A 1999 Jan 5;96(1):318]. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13278-83
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory