Dlg2 Gene Detail

Summary

• Symbol
  Dlg2
• Name
  discs large MAGUK scaffold protein 2
• Synonyms
  A330103J02Rik, B230218P12Rik, B330007M19Rik, Chapsyn-110, Dlgh2, Gm21505, LOC382816, PSD93

• Feature Type
  protein coding gene
• IDs
  MGI:1344351
  NCBI Gene: 23859
• Alliance
  gene page
• Transcription Start Sites
  82 TSS

Location &
Maps

• Sequence Map
  Chr7:90125880-92098455 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 51.07 cM
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  55347 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344351	protein coding gene	Chr7:90125399-92098455 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032510	protein coding gene	Chr7:93553822-94996250 (+)
A/J	MGP_AJ_G0032484	protein coding gene	Chr7:91266035-92623800 (+)
AKR/J	MGP_AKRJ_G0032420	protein coding gene	Chr7:93409980-94826094 (+)
BALB/cJ	MGP_BALBcJ_G0032495	protein coding gene	Chr7:90915744-92292131 (+)
C3H/HeJ	MGP_C3HHeJ_G0032210	protein coding gene	Chr7:93805522-95206226 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032993	protein coding gene	Chr7:97193223-98641842 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029988	protein coding gene	Chr7:94120769-95431938 (+)
CAST/EiJ	MGP_CASTEiJ_G0031537	protein coding gene	Chr7:85244489-86683162 (+)
CBA/J	MGP_CBAJ_G0032177	protein coding gene	Chr7:100445595-101988714 (+)
DBA/2J	MGP_DBA2J_G0032329	protein coding gene	Chr7:89714390-91065749 (+)
FVB/NJ	MGP_FVBNJ_G0032285	protein coding gene	Chr7:89571597-90899104 (+)
LP/J	MGP_LPJ_G0032418	protein coding gene	Chr7:94806373-96245277 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032319	protein coding gene	Chr7:101501727-103121707 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033015	protein coding gene	Chr7:92717180-94147830 (+)
PWK/PhJ	MGP_PWKPhJ_G0031255	protein coding gene	Chr7:82751165-84125721 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031098	protein coding gene	Chr7:80007621-81452234 (+)
WSB/EiJ	MGP_WSBEiJ_G0031654	protein coding gene	Chr7:93374015-94806271 (+)

Homology

• Human Ortholog
  DLG2, discs large MAGUK scaffold protein 2

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  DLG2, discs large MAGUK scaffold protein 2
  
• Synonyms
  chapsyn-110, PPP1R58, PSD-93, PSD93
• Links
  HGNC:2901

  NCBI Gene ID: 1740

  neXtProt AC: NX_Q15700

  UniProt: Q15700

  
  
• Chr Location
  11q14.1; chr11:83455012-85628373 (-)  GRCh38

---

• MGI Vertebrate Homology
  Dlg2 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: DLG2
• Protein SuperFamily
  MAGUK_DLGH
• Gene Tree
  Dlg2
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 1 allele in 2 genetic backgrounds
  4 phenotypes from multigenic genotypes
  51 phenotype references
  

• All Mutations and Alleles
  9
• Chemically induced (other)
  1
• Radiation induced
  2
• Targeted
  6
• Genomic Mutations
  3 involving Dlg2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  62 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele display lower surface expression of NMDA receptor (NMDAR) subunits NR2A and NR2B in dorsal horn neurons and significantly reduced NMDAR-mediated excitatory synaptic currents and NMDAR-dependent persistent inflammatory or nerve injury-induced neuropathic pain.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  71
• GO References
  26

Expression

• Assay Results
  822
• Tissues
  42
• cDNA Data
  16
• Literature Summary
  11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA DLG2
  Xenbase dlg2
  ZFIN dlg2

Sequences &
Gene Models

• All Sequences
  182
• RefSeq
  96
• UniProt
  12
• CCDS
  CCDS40021.1, CCDS57562.1

• Ensembl
  ENSMUSG00000052572 (Evidence)
• NCBI Gene
  23859

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000052572	Ensembl Gene Model | MGI Sequence Detail	1972576	C57BL/6J
transcript	ENSMUST00000231777	Ensembl | MGI Sequence Detail	7801	Not Applicable
polypeptide	ENSMUSP00000155862	Ensembl | MGI Sequence Detail	994	Not Applicable

Protein
Information

• UniProt
  12 Sequences
• Protein Ontology
  PR:000006512 disks large homolog 2
  (term hierarchy)
• PDB
  2WL7
• InterPro Domains
  IPR016313 Disks large 1-like
  IPR019583 Disks large homolog 1-4, PDZ-associated domain
  IPR019590 Disks large homologue 1, N-terminal PEST domain
  IPR035759 Disks Large homologue 2, SH3 domain
  IPR020590 Guanylate kinase, conserved site
  IPR008144 Guanylate kinase-like domain
  IPR008145 Guanylate kinase/L-type calcium channel beta subunit
  IPR015143 L27-1
  IPR004172 L27 domain
  IPR036892 L27 domain superfamily
  IPR050716 Membrane-associated guanylate kinase
  IPR001478 PDZ domain
  IPR036034 PDZ superfamily
  IPR027417 P-loop containing nucleoside triphosphate hydrolase
  IPR001452 SH3 domain
  IPR036028 SH3-like domain superfamily
  IPR050614 Synaptic Scaffolding LAP/MAGUK Families
• GlyGen
  Q91XM9 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)

Molecular
Reagents

• All nucleic 16

  cDNA 16

  
  

  Microarray probesets 7

Other
Accession IDs

MGI:1926130, MGI:2443779, MGI:2686043, MGI:5434860

References

• Summaries
  All 112

  Developmental Gene Expression 11

  Gene Ontology 26

  Phenotypes 51
• Earliest
  J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
• Latest
  J:353047 Nevorankova P, et al., Region-specific gene expression profiling of early mouse mandible uncovered SATB2 as a key molecule for teeth patterning. Sci Rep. 2024 Aug 6;14(1):18212

TSS for Dlg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67766	Chr7:90125868-90125889 (+)	-1 bp
Tssr67767	Chr7:90125891-90125920 (+)	26 bp
Tssr67768	Chr7:90168745-90168749 (+)	42,867 bp
Tssr67769	Chr7:90189472-90189479 (+)	63,596 bp
Tssr67770	Chr7:90264286-90264300 (+)	138,413 bp
Tssr67775	Chr7:90603932-90603959 (+)	478,066 bp
Tssr67776	Chr7:90614994-90615007 (+)	489,121 bp
Tssr67777	Chr7:90621594-90621611 (+)	495,723 bp
Tssr67778	Chr7:90621635-90621650 (+)	495,763 bp
Tssr67779	Chr7:90739905-90739935 (+)	614,040 bp
Tssr67780	Chr7:90739936-90739959 (+)	614,068 bp
Tssr67781	Chr7:90740018-90740055 (+)	614,157 bp
Tssr67782	Chr7:90740081-90740095 (+)	614,208 bp
Tssr67783	Chr7:90740096-90740110 (+)	614,223 bp
Tssr67784	Chr7:90740120-90740135 (+)	614,248 bp
Tssr67785	Chr7:90740140-90740159 (+)	614,270 bp
Tssr67786	Chr7:90758003-90758013 (+)	632,128 bp
Tssr67787	Chr7:90758025-90758037 (+)	632,151 bp
Tssr67788	Chr7:90767517-90767522 (+)	641,640 bp
Tssr67790	Chr7:90792884-90792889 (+)	667,007 bp
Tssr67792	Chr7:90811741-90811752 (+)	685,867 bp
Tssr67793	Chr7:90811867-90811898 (+)	686,003 bp
Tssr67794	Chr7:90825987-90825996 (+)	700,112 bp
Tssr67795	Chr7:90826119-90826136 (+)	700,248 bp
Tssr67796	Chr7:90875726-90875730 (+)	749,848 bp
Tssr67797	Chr7:90899956-90899976 (+)	774,086 bp
Tssr67798	Chr7:90902483-90902493 (+)	776,608 bp
Tssr67799	Chr7:90911329-90911352 (+)	785,461 bp
Tssr67800	Chr7:90911517-90911546 (+)	785,652 bp
Tssr67801	Chr7:90911548-90911566 (+)	785,677 bp
Tssr67802	Chr7:90911573-90911582 (+)	785,698 bp
Tssr67803	Chr7:90911900-90911930 (+)	786,035 bp
Tssr67804	Chr7:90911931-90911943 (+)	786,057 bp
Tssr67805	Chr7:90916577-90916581 (+)	790,699 bp
Tssr67806	Chr7:90918518-90918522 (+)	792,640 bp
Tssr67807	Chr7:90993718-90993723 (+)	867,841 bp
Tssr67808	Chr7:91003428-91003433 (+)	877,551 bp
Tssr67809	Chr7:91113075-91113102 (+)	987,209 bp
Tssr67810	Chr7:91137900-91137902 (+)	1,012,021 bp
Tssr67811	Chr7:91157852-91157856 (+)	1,031,974 bp
Tssr67812	Chr7:91158352-91158357 (+)	1,032,475 bp
Tssr67813	Chr7:91192173-91192201 (+)	1,066,307 bp
Tssr67814	Chr7:91192202-91192251 (+)	1,066,347 bp
Tssr67815	Chr7:91192272-91192303 (+)	1,066,408 bp
Tssr67820	Chr7:91321589-91321598 (+)	1,195,714 bp
Tssr67821	Chr7:91321638-91321656 (+)	1,195,767 bp
Tssr67822	Chr7:91321663-91321691 (+)	1,195,797 bp
Tssr67823	Chr7:91321694-91321705 (+)	1,195,820 bp
Tssr67824	Chr7:91321845-91321865 (+)	1,195,975 bp
Tssr67825	Chr7:91360871-91360895 (+)	1,235,003 bp
Tssr67826	Chr7:91403815-91403831 (+)	1,277,943 bp
Tssr67827	Chr7:91711600-91711633 (+)	1,585,737 bp
Tssr67828	Chr7:91778916-91778920 (+)	1,653,038 bp
Tssr67829	Chr7:91792292-91792300 (+)	1,666,416 bp
Tssr67830	Chr7:91829818-91829829 (+)	1,703,944 bp
Tssr67831	Chr7:91829886-91829942 (+)	1,704,034 bp
Tssr67832	Chr7:91830082-91830104 (+)	1,704,213 bp
Tssr67833	Chr7:91884148-91884178 (+)	1,758,283 bp
Tssr67834	Chr7:91884182-91884205 (+)	1,758,314 bp
Tssr67835	Chr7:91884287-91884331 (+)	1,758,429 bp
Tssr67836	Chr7:91884343-91884352 (+)	1,758,468 bp
Tssr67837	Chr7:91885376-91885381 (+)	1,759,499 bp
Tssr67838	Chr7:91908031-91908040 (+)	1,782,156 bp
Tssr67839	Chr7:91973867-91973871 (+)	1,847,989 bp
Tssr67840	Chr7:91985798-91985836 (+)	1,859,937 bp
Tssr67841	Chr7:91997424-91997454 (+)	1,871,559 bp
Tssr67842	Chr7:92042617-92042621 (+)	1,916,739 bp
Tssr67843	Chr7:92051906-92051914 (+)	1,926,030 bp
Tssr67844	Chr7:92069995-92069999 (+)	1,944,117 bp
Tssr67845	Chr7:92096488-92096493 (+)	1,970,611 bp
Tssr67846	Chr7:92096587-92096599 (+)	1,970,713 bp
Tssr67847	Chr7:92096639-92096650 (+)	1,970,765 bp
Tssr67848	Chr7:92096675-92096686 (+)	1,970,801 bp
Tssr67849	Chr7:92096716-92096733 (+)	1,970,845 bp
Tssr67850	Chr7:92096769-92096778 (+)	1,970,894 bp
Tssr67851	Chr7:92096781-92096797 (+)	1,970,909 bp
Tssr67852	Chr7:92096815-92096816 (+)	1,970,936 bp
Tssr67853	Chr7:92096820-92096841 (+)	1,970,951 bp
Tssr67854	Chr7:92096843-92096854 (+)	1,970,969 bp
Tssr67855	Chr7:92096858-92096865 (+)	1,970,982 bp
Tssr67856	Chr7:92096926-92096939 (+)	1,971,053 bp
Tssr67857	Chr7:92098170-92098174 (+)	1,972,292 bp