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Hcst Gene Detail
Summary
  • Symbol
    Hcst
  • Name
    hematopoietic cell signal transducer
  • Synonyms
    DAP10, KAP10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344360
    NCBI Gene: 23900
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30117137-30119279 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 17.45 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344360
 protein coding gene Chr7:30117137-30119279 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032018
 protein coding gene Chr7:29403656-29407876 (-)
A/J MGP_AJ_G0031995
 protein coding gene Chr7:28621634-28623766 (-)
AKR/J MGP_AKRJ_G0031928
 protein coding gene Chr7:29352123-29354260 (-)
BALB/cJ MGP_BALBcJ_G0032002
 protein coding gene Chr7:28800059-28802191 (-)
C3H/HeJ MGP_C3HHeJ_G0031721
 protein coding gene Chr7:29797017-29799154 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032468
 protein coding gene Chr7:30363925-30366062 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029518
 protein coding gene Chr7:29656419-29658709 (-)
CAST/EiJ MGP_CASTEiJ_G0031055
 protein coding gene Chr7:23053987-23056117 (-)
CBA/J MGP_CBAJ_G0031687
 protein coding gene Chr7:31811528-31813665 (-)
DBA/2J MGP_DBA2J_G0031839
 protein coding gene Chr7:28351361-28353492 (-)
FVB/NJ MGP_FVBNJ_G0031796
 protein coding gene Chr7:28470876-28473013 (-)
LP/J MGP_LPJ_G0031920
 protein coding gene Chr7:29724251-29726383 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031832
 protein coding gene Chr7:31062891-31066362 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032496
 protein coding gene Chr7:28850838-28854109 (-)
PWK/PhJ MGP_PWKPhJ_G0030781
 protein coding gene Chr7:23388700-23390836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030614
 protein coding gene Chr7:19857611-19859735 (-)
WSB/EiJ MGP_WSBEiJ_G0031165
 protein coding gene Chr7:29235670-29237831 (-)



Homology
more
  • Human Ortholog
    HCST, hematopoietic cell signal transducer
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCST, hematopoietic cell signal transducer
  • Synonyms
    DAP10, KAP10, PIK3AP
  • Links
    NCBI Gene ID: 10870
    neXtProt AC: NX_Q9UBK5
    UniProt: Q9UBK5

  • Chr Location
    19q13.12; chr19:35902529-35904377 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit osteopetrosis, decreased CD8+ T cells involved in tumor rejection, decreased uterine NK cells, and abnormal implantation site morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    5
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23900 NCBI Gene Model | MGI Sequence Detail 2143 C57BL/6J ±  kb
    transcript NM_011827 RefSeq | MGI Sequence Detail 452 Not Specified  
    polypeptide Q9QUJ0 UniProt | EBI | MGI Sequence Detail 79 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:56494 Wu J, et al., An activating immunoreceptor complex formed by NKG2D and DAP10 [see comments]. Science. 1999 Jul 30;285(5428):730-2
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory