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Dand5 Gene Detail
Summary
  • Symbol
    Dand5
  • Name
    DAN domain family member 5, BMP antagonist
  • Synonyms
    Cerl-2, Cerl2, Cerr2, coco, Dte, GREM3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344365
    NCBI Gene: 23863
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85542034-85558894 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    477 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344365
 protein coding gene Chr8:85542033-85559038 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033870
 protein coding gene Chr8:85732000-85741414 (-)
A/J MGP_AJ_G0033853
 protein coding gene Chr8:82357987-82365160 (-)
AKR/J MGP_AKRJ_G0033779
 protein coding gene Chr8:84793149-84803884 (-)
BALB/cJ MGP_BALBcJ_G0033846
 protein coding gene Chr8:82483730-82492464 (-)
C3H/HeJ MGP_C3HHeJ_G0033556
 protein coding gene Chr8:85417685-85426042 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034366
 protein coding gene Chr8:89020351-89027795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031308
 protein coding gene Chr8:76150670-76157918 (-)
CAST/EiJ MGP_CASTEiJ_G0032886
 protein coding gene Chr8:84843192-84851038 (-)
CBA/J MGP_CBAJ_G0033532
 protein coding gene Chr8:92062208-92069369 (-)
DBA/2J MGP_DBA2J_G0033685
 protein coding gene Chr8:81997759-82004919 (-)
FVB/NJ MGP_FVBNJ_G0033633
 protein coding gene Chr8:80942775-80949380 (-)
LP/J MGP_LPJ_G0033777
 protein coding gene Chr8:85846158-85853306 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033675
 protein coding gene Chr8:94614548-94621709 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034383
 protein coding gene Chr8:84783380-84792207 (-)
PWK/PhJ MGP_PWKPhJ_G0032590
 protein coding gene Chr8:81242575-81250621 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032426
 protein coding gene Chr8:83595654-83602150 (-)
WSB/EiJ MGP_WSBEiJ_G0032999
 protein coding gene Chr8:85213393-85221333 (-)



Homology
more
  • Human Ortholog
    DAND5, DAN domain BMP antagonist family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAND5, DAN domain BMP antagonist family member 5
  • Synonyms
    CER2, CERL2, CKTSF1B3, COCO, CRL2, DANTE, GREM3, SP1
  • Links
    NCBI Gene ID: 199699
    neXtProt AC: NX_Q8N907
    UniProt: Q8N907

  • Chr Location
    19p13.13; chr19:12965159-12974760 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial neonatal lethality with left pulmonary isomerism, abnormal heart looping, atrial and ventricular septal defects and thoracic situs inversus and surviving pups display partial premature death with abdominal organ position abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    10
  • cDNA Data
    10
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23863 NCBI Gene Model | MGI Sequence Detail 16861 C57BL/6J ±  kb
    transcript NM_201227 RefSeq | MGI Sequence Detail 1584 C57BL/6  
    polypeptide Q76LW6 UniProt | EBI | MGI Sequence Detail 185 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 11
      Primer pair 2
      Other 10

      Microarray probesets 1
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 38
      Gene Ontology 6
      Phenotypes 46
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory