Creg1 MGI Mouse Gene Detail - MGI:1344382 - cellular repressor of E1A-stimulated genes 1

Symbol

Creg1
Name

cellular repressor of E1A-stimulated genes 1
Synonyms

Creg

Feature Type

protein coding gene
IDs

MGI:1344382
NCBI Gene: 433375
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr1:165591327-165602878 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 73.11 cM
Mapping Data

3 experiments

SNPs within 2kb

501 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344382	protein coding gene	Chr1:165591315-165602878 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016697	protein coding gene	Chr1:171268086-171280995 (+)
A/J	MGP_AJ_G0016678	protein coding gene	Chr1:164276570-164287318 (+)
AKR/J	MGP_AKRJ_G0016644	protein coding gene	Chr1:169252280-169265199 (+)
BALB/cJ	MGP_BALBcJ_G0016639	protein coding gene	Chr1:164774037-164785877 (+)
C3H/HeJ	MGP_C3HHeJ_G0016463	protein coding gene	Chr1:169474262-169486119 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017100	protein coding gene	Chr1:177017484-177028560 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014809	protein coding gene	Chr1:156170825-156182146 (+)
CAST/EiJ	MGP_CASTEiJ_G0016043	protein coding gene	Chr1:169073029-169085132 (+)
CBA/J	MGP_CBAJ_G0016438	protein coding gene	Chr1:183310076-183325342 (+)
DBA/2J	MGP_DBA2J_G0016544	protein coding gene	Chr1:163165331-163177826 (+)
FVB/NJ	MGP_FVBNJ_G0016542	protein coding gene	Chr1:161596602-161610714 (+)
LP/J	MGP_LPJ_G0016615	protein coding gene	Chr1:172324718-172335925 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016567	protein coding gene	Chr1:190784810-190796213 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017136	protein coding gene	Chr1:169116527-169130515 (+)
PWK/PhJ	MGP_PWKPhJ_G0015829	protein coding gene	Chr1:162363851-162376288 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015616	protein coding gene	Chr1:167957722-167969237 (+)
WSB/EiJ	MGP_WSBEiJ_G0016105	protein coding gene	Chr1:169266093-169278554 (+)

Human Ortholog

CREG1, cellular repressor of E1A stimulated genes 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CREG1, cellular repressor of E1A stimulated genes 1
Synonyms

CREG
Links

HGNC:2351

NCBI Gene ID: 8804

neXtProt AC: NX_O75629

UniProt: O75629
Chr Location

1q24.2; chr1:167529117-167553805 (-) GRCh38

MGI Vertebrate Homology

Creg1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CREG1
Protein SuperFamily

CREG
Gene Tree

Creg1

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

5
Targeted

3
Genomic Mutations

2 involving Creg1
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a knock-out allele exhibit decreased neovascularization after induction of hindlimb ischemia, and show increased infarction size, elevated cardiomyocyte apoptosis and impaired autophagy following myocardial ischemia/reperfusion injury.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

46
cDNA Data

11
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase creg1

ZFIN creg1

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All Sequences

63
RefSeq

3
UniProt

3
CCDS

CCDS35759.1

Ensembl

ENSMUSG00000040713 (Evidence)
NCBI Gene

433375

			Length	Strain/Species	Flank
genomic	433375	NCBI Gene Model \| MGI Sequence Detail	11552	C57BL/6J	± kb
transcript	NR_149310	RefSeq \| MGI Sequence Detail	2323	C57BL/6
polypeptide	O88668	UniProt \| EBI \| MGI Sequence Detail	220	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005863 protein CREG1

(term hierarchy)
InterPro Domains

IPR014631 Cellular repressor of E1A-stimulated genes (CREG)

IPR012349 FMN-binding split barrel
GlyGen

O88668 4 sites, 7 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGI:2138129

Summaries

All 56

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 19
Earliest

J:53002 Veal E, et al., A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. Mol Cell Biol. 1998 Sep;18(9):5032-41
Latest

J:344665 Liu D, et al., The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Exp Mol Med. 2023 Sep;55(9):2025-2038

TSS for Creg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9817	Chr1:165591321-165591353 (+)	10 bp
Tssr9818	Chr1:165593415-165593420 (+)	2,091 bp
Tssr9819	Chr1:165593677-165593720 (+)	2,372 bp
Tssr9820	Chr1:165594729-165594756 (+)	3,416 bp
Tssr9821	Chr1:165594841-165594862 (+)	3,525 bp
Tssr9822	Chr1:165595283-165595339 (+)	3,984 bp
Tssr9823	Chr1:165596961-165597005 (+)	5,656 bp
Tssr9824	Chr1:165597390-165597399 (+)	6,068 bp
Tssr9825	Chr1:165598211-165598286 (+)	6,922 bp
Tssr9826	Chr1:165601475-165601522 (+)	10,172 bp
Tssr9827	Chr1:165601841-165601854 (+)	10,521 bp
Tssr9828	Chr1:165601859-165601868 (+)	10,537 bp
Tssr9829	Chr1:165601869-165601884 (+)	10,550 bp
Tssr9830	Chr1:165601892-165601902 (+)	10,570 bp
Tssr9831	Chr1:165601928-165601949 (+)	10,612 bp
Tssr9832	Chr1:165601977-165601999 (+)	10,661 bp
Tssr9833	Chr1:165602045-165602052 (+)	10,722 bp
Tssr9834	Chr1:165602143-165602154 (+)	10,822 bp
Tssr9835	Chr1:165602164-165602175 (+)	10,843 bp
Tssr9836	Chr1:165602181-165602192 (+)	10,860 bp
Tssr9837	Chr1:165602292-165602296 (+)	10,967 bp
Tssr9838	Chr1:165602325-165602336 (+)	11,004 bp
Tssr9839	Chr1:165602374-165602387 (+)	11,054 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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