Med24 MGI Mouse Gene Detail - MGI:1344385 - mediator complex subunit 24

Symbol

Med24
Name

mediator complex subunit 24
Synonyms

100kDa, D11Ertd307e, DRIP100, Gse2, Pparb2, R75526, Thrap4, Trap100

Feature Type

protein coding gene
IDs

MGI:1344385
NCBI Gene: 23989
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:98595423-98620245 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.46 cM
Mapping Data

3 experiments

SNPs within 2kb

735 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344385	protein coding gene	Chr11:98595417-98620261 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019070	protein coding gene	Chr11:101299431-101326219 (-)
A/J	MGP_AJ_G0019038	protein coding gene	Chr11:97060187-97086037 (-)
AKR/J	MGP_AKRJ_G0019008	protein coding gene	Chr11:100070219-100095060 (-)
BALB/cJ	MGP_BALBcJ_G0019012	protein coding gene	Chr11:97556057-97580883 (-)
C3H/HeJ	MGP_C3HHeJ_G0018825	protein coding gene	Chr11:100210125-100235491 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019463	protein coding gene	Chr11:104393626-104420344 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017095	protein coding gene	Chr11:94617693-94644949 (-)
CAST/EiJ	MGP_CASTEiJ_G0018379	protein coding gene	Chr11:101195256-101219917 (-)
CBA/J	MGP_CBAJ_G0018796	protein coding gene	Chr11:108750378-108775378 (-)
DBA/2J	MGP_DBA2J_G0018904	protein coding gene	Chr11:96619445-96644282 (-)
FVB/NJ	MGP_FVBNJ_G0018893	protein coding gene	Chr11:96129779-96154622 (-)
LP/J	MGP_LPJ_G0018974	protein coding gene	Chr11:101756988-101782646 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018920	protein coding gene	Chr11:108467748-108493287 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019503	protein coding gene	Chr11:100414245-100440726 (-)
PWK/PhJ	MGP_PWKPhJ_G0018150	protein coding gene	Chr11:97651845-97677684 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017939	protein coding gene	Chr11:100156313-100183494 (-)
WSB/EiJ	MGP_WSBEiJ_G0018428	protein coding gene	Chr11:100364871-100391240 (-)

Human Ortholog

MED24, mediator complex subunit 24

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED24, mediator complex subunit 24
Synonyms

ARC100, CRSP100, CRSP4, DRIP100, MED5, THRAP4, TRAP100
Links

HGNC:22963

NCBI Gene ID: 9862

neXtProt AC: NX_O75448

UniProt: O75448
Chr Location

17q21.1; chr17:40019097-40061215 (-) GRCh38

MGI Vertebrate Homology

Med24 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MED24
Gene Tree

Med24

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Phenotype Summary

16 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

1
Gene trapped

6
Targeted

5
Genomic Mutations

1 involving Med24
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice die prior to birth exhibiting abnormal heart development, neural tube defects, and anemia.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

795
Tissues

71
cDNA Data

241
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase med24

ZFIN med24

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All Sequences

93
RefSeq

12
UniProt

4
CCDS

CCDS25361.2, CCDS88247.1

Ensembl

ENSMUSG00000017210 (Evidence)
NCBI Gene

23989

			Length	Strain/Species	Flank
genomic	23989	NCBI Gene Model \| MGI Sequence Detail	24823	C57BL/6J	± kb
transcript	NM_001361994	RefSeq \| MGI Sequence Detail	3513	ZRU/MplStud
polypeptide	Q99K74	UniProt \| EBI \| MGI Sequence Detail	987	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010296 mediator of RNA polymerase II transcription subunit 24

(term hierarchy)
PDB

6W1S, 8T1I, 8T1L
InterPro Domains

IPR021429 Mediator complex, subunit Med24,
GlyGen

Q99K74 1 site, 1 N-linked glycan (1 site)

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All nucleic 244

cDNA 242

Primer pair 2

Microarray probesets 4

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MGI:1098276, MGI:1098829, MGI:2144420, MGI:2144562, MGI:2144713

Summaries

All 57

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 14
Earliest

J:43245 Gudkov AV, et al., Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3744-8
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Med24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110585	Chr11:98620227-98620258 (-)	2 bp
Tssr110584	Chr11:98598583-98598603 (-)	21,652 bp
Tssr110583	Chr11:98598562-98598569 (-)	21,679 bp
Tssr110582	Chr11:98598471-98598482 (-)	21,768 bp
Tssr110581	Chr11:98598396-98598408 (-)	21,843 bp
Tssr110580	Chr11:98597380-98597396 (-)	22,857 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24