C1ql1 MGI Mouse Gene Detail - MGI:1344400 - complement component 1, q subcomponent-like 1

Symbol

C1ql1
Name

complement component 1, q subcomponent-like 1
Synonyms

C1qrf

Feature Type

protein coding gene
IDs

MGI:1344400
NCBI Gene: 23829
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:102830090-102837514 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.48 cM, cytoband D
Mapping Data

1 experiment

SNPs within 2kb

246 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344400	protein coding gene	Chr11:102830090-102837542 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019251	protein coding gene	Chr11:105973132-105980555 (-)
A/J	MGP_AJ_G0019219	protein coding gene	Chr11:101482965-101490397 (-)
AKR/J	MGP_AKRJ_G0019188	protein coding gene	Chr11:104616867-104624290 (-)
BALB/cJ	MGP_BALBcJ_G0019193	protein coding gene	Chr11:101959747-101967171 (-)
C3H/HeJ	MGP_C3HHeJ_G0019002	protein coding gene	Chr11:104843943-104851366 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019642	protein coding gene	Chr11:109253639-109261063 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017268	protein coding gene	Chr11:98906655-98914022 (-)
CAST/EiJ	MGP_CASTEiJ_G0018556	protein coding gene	Chr11:105851228-105858637 (-)
CBA/J	MGP_CBAJ_G0018971	protein coding gene	Chr11:113794261-113801698 (-)
DBA/2J	MGP_DBA2J_G0019083	protein coding gene	Chr11:100997472-101004895 (-)
FVB/NJ	MGP_FVBNJ_G0019073	protein coding gene	Chr11:100539914-100547336 (-)
LP/J	MGP_LPJ_G0019152	protein coding gene	Chr11:106491568-106498991 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019104	protein coding gene	Chr11:113224485-113231909 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019680	protein coding gene	Chr11:104998751-105006174 (-)
PWK/PhJ	MGP_PWKPhJ_G0018319	protein coding gene	Chr11:102069737-102077148 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018111	protein coding gene	Chr11:104759238-104766706 (-)
WSB/EiJ	MGP_WSBEiJ_G0018605	protein coding gene	Chr11:104994345-105001775 (-)

Human Ortholog

C1QL1, complement C1q like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QL1, complement C1q like 1
Synonyms

C1QRF, C1QTNF14, CRF, CTRP14
Links

HGNC:24182

NCBI Gene ID: 10882

neXtProt AC: NX_O75973

UniProt: O75973
Chr Location

17q21.31; chr17:44959693-44968303 (-) GRCh38

MGI Vertebrate Homology

C1ql1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C1QL1
Gene Tree

C1ql1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Targeted

6
Genomic Mutations

1 involving C1ql1
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for a null allele exhibit impaired motor learning with alterned climbing fiber electrophysiology.

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

36
cDNA Data

8
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase c1ql1

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All Sequences

31
RefSeq

2
UniProt

4
CCDS

CCDS25509.1

Ensembl

ENSMUSG00000045532 (Evidence)
NCBI Gene

23829

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045532	Ensembl Gene Model \| MGI Sequence Detail	7425	C57BL/6J	± kb
transcript	ENSMUST00000057849	Ensembl \| MGI Sequence Detail	1473	Not Applicable
polypeptide	ENSMUSP00000050469	Ensembl \| MGI Sequence Detail	258	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004879 C1q-related factor

(term hierarchy)
PDB

4D7Y, 4QQ2
InterPro Domains

IPR001073 C1q domain

IPR050822 Cerebellin Synaptic Organizer

IPR008160 Collagen triple helix repeat

IPR008983 Tumour necrosis factor-like domain superfamily

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All nucleic 11

cDNA 8

Primer pair 2

Other 1

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 14
Earliest

J:51998 Berube NG, et al., Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function. Brain Res Mol Brain Res. 1999 Jan 8;63(2):233-40
Latest

J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7

TSS for C1ql1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111129	Chr11:102837595-102837604 (-)	-86 bp
Tssr111128	Chr11:102837567-102837577 (-)	-58 bp
Tssr111127	Chr11:102837527-102837551 (-)	-25 bp
Tssr111126	Chr11:102837374-102837394 (-)	130 bp
Tssr111125	Chr11:102836837-102836882 (-)	654 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24