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Rnf144a Gene Detail
Summary
  • Symbol
    Rnf144a
  • Name
    ring finger protein 144A
  • Synonyms
    Rnf144, UIP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344401
    NCBI Gene: 108089
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:26356796-26465296 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 9.69 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3736 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344401
 protein coding gene Chr12:26350963-26465296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019636
 protein coding gene Chr12:24037588-24148042 (-)
A/J MGP_AJ_G0019603
 protein coding gene Chr12:23401110-23518910 (-)
AKR/J MGP_AKRJ_G0019574
 protein coding gene Chr12:24164008-24274692 (-)
BALB/cJ MGP_BALBcJ_G0019580
 protein coding gene Chr12:23644007-23753358 (-)
C3H/HeJ MGP_C3HHeJ_G0019384
 protein coding gene Chr12:24047086-24165079 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020028
 protein coding gene Chr12:24803634-24919529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017652
 protein coding gene Chr12:22839554-22952145 (-)
CAST/EiJ MGP_CASTEiJ_G0018939
 protein coding gene Chr12:19033995-19146293 (-)
CBA/J MGP_CBAJ_G0019355
 protein coding gene Chr12:25587864-25707506 (-)
DBA/2J MGP_DBA2J_G0019469
 protein coding gene Chr12:23224973-23332375 (-)
FVB/NJ MGP_FVBNJ_G0019460
 protein coding gene Chr12:23095954-23205589 (-)
LP/J MGP_LPJ_G0019539
 protein coding gene Chr12:24098548-24212797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019495
 protein coding gene Chr12:25379329-25493110 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020067
 protein coding gene Chr12:23718310-23829353 (-)
PWK/PhJ MGP_PWKPhJ_G0018706
 protein coding gene Chr12:17974175-18084763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018494
 protein coding gene Chr12:18225015-18332927 (-)
WSB/EiJ MGP_WSBEiJ_G0018990
 protein coding gene Chr12:23902071-24016919 (-)



Homology
more
  • Human Ortholog
    RNF144A, ring finger protein 144A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF144A, ring finger protein 144A
  • Synonyms
    hUIP4, RNF144, UBCE7IP4, UIP4
  • Links
    NCBI Gene ID: 9781
    neXtProt AC: NX_P50876
    UniProt: P50876

  • Chr Location
    2p25.1; chr2:6917412-7076367 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased susceptibility to HSV-1 infection and impaired DNA virus or exogenous cytosolic-DNA triggered innate immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108089 NCBI Gene Model | MGI Sequence Detail 108501 C57BL/6J ±  kb
    transcript NM_001413480 RefSeq | MGI Sequence Detail 5290 C57BL/6  
    polypeptide Q925F3 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144788
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory