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Sigirr Gene Detail
Summary
  • Symbol
    Sigirr
  • Name
    single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
  • Synonyms
    Sigirr, Tir8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344402
    NCBI Gene: 24058
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140671088-140680485 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344402
 protein coding gene Chr7:140671088-140680493 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033210
 protein coding gene Chr7:146260888-146270254 (-)
A/J MGP_AJ_G0033192
 protein coding gene Chr7:142079656-142089044 (-)
AKR/J MGP_AKRJ_G0033124
 protein coding gene Chr7:145995750-146005117 (-)
BALB/cJ MGP_BALBcJ_G0033193
 protein coding gene Chr7:141820976-141830349 (-)
C3H/HeJ MGP_C3HHeJ_G0032907
 protein coding gene Chr7:145746130-145755512 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033704
 protein coding gene Chr7:151610990-151620359 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030677
 protein coding gene Chr7:143290961-143300421 (-)
CAST/EiJ MGP_CASTEiJ_G0032237
 protein coding gene Chr7:138049956-138059288 (-)
CBA/J MGP_CBAJ_G0032879
 protein coding gene Chr7:156719688-156729077 (-)
DBA/2J MGP_DBA2J_G0033031
 protein coding gene Chr7:140028966-140038881 (-)
FVB/NJ MGP_FVBNJ_G0032984
 protein coding gene Chr7:139931602-139941311 (-)
LP/J MGP_LPJ_G0033126
 protein coding gene Chr7:147746640-147756010 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033017
 protein coding gene Chr7:157403385-157414045 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033724
 protein coding gene Chr7:144975434-144984812 (-)
PWK/PhJ MGP_PWKPhJ_G0031941
 protein coding gene Chr7:133303552-133309337 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031788
 protein coding gene Chr7:131787386-131796707 (-)
WSB/EiJ MGP_WSBEiJ_G0032348
 protein coding gene Chr7:145922008-145927591 (-)



Homology
more
  • Human Ortholog
    SIGIRR, single Ig and TIR domain containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGIRR, single Ig and TIR domain containing
  • Synonyms
    IL-1R8, TIR8
  • Links
    NCBI Gene ID: 59307
    neXtProt AC: NX_Q6IA17
    UniProt: Q6IA17

  • Chr Location
    11p15.5; chr11:405715-417455 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
When challenged, homozygous mutant mice show an increased inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    33
  • cDNA Data
    37
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025494 Ensembl Gene Model | MGI Sequence Detail 9398 C57BL/6J ±  kb
    transcript ENSMUST00000097958 Ensembl | MGI Sequence Detail 1990 Not Applicable  
    polypeptide ENSMUSP00000095571 Ensembl | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000014863 single Ig IL-1-related receptor
      (term hierarchy)
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR015621 Interleukin-1 receptor family
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    • GlyGen
      Q9JLZ8 6 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2141892
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 43
    • Earliest
      J:55824 Thomassen E, et al., Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine. 1999 Jun;11(6):389-99
    • Latest
      J:313772 Allaire JM, et al., Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids. Sci Rep. 2021 Apr 15;11(1):8206
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory