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Ptpn21 Gene Detail
Summary
  • Symbol
    Ptpn21
  • Name
    protein tyrosine phosphatase, non-receptor type 21
  • Synonyms
    PTPD1, PTPRL10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344406
    NCBI Gene: 24000
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:98643000-98703664 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 49.88 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1675 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344406
 protein coding gene Chr12:98643000-98703664 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020007
 protein coding gene Chr12:100075475-100140286 (-)
A/J MGP_AJ_G0019962
 protein coding gene Chr12:96310461-96373324 (-)
AKR/J MGP_AKRJ_G0019938
 protein coding gene Chr12:98917774-98979783 (-)
BALB/cJ MGP_BALBcJ_G0019948
 protein coding gene Chr12:96644185-96706217 (-)
C3H/HeJ MGP_C3HHeJ_G0019750
 protein coding gene Chr12:99467418-99531337 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020397
 protein coding gene Chr12:103125528-103187026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018011
 protein coding gene Chr12:93284152-93343294 (-)
CAST/EiJ MGP_CASTEiJ_G0019296
 protein coding gene Chr12:94516110-94579179 (-)
CBA/J MGP_CBAJ_G0019722
 protein coding gene Chr12:106947431-107022858 (-)
DBA/2J MGP_DBA2J_G0019833
 protein coding gene Chr12:95735131-95797877 (-)
FVB/NJ MGP_FVBNJ_G0019822
 protein coding gene Chr12:94456338-94517619 (-)
LP/J MGP_LPJ_G0019909
 protein coding gene Chr12:99903313-99968482 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019864
 protein coding gene Chr12:110637403-110700801 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020426
 protein coding gene Chr12:98481170-98544470 (-)
PWK/PhJ MGP_PWKPhJ_G0019060
 protein coding gene Chr12:90352672-90413756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018856
 protein coding gene Chr12:92642019-92705114 (-)
WSB/EiJ MGP_WSBEiJ_G0019350
 protein coding gene Chr12:99310647-99376475 (-)



Homology
more
  • Human Ortholog
    PTPN21, protein tyrosine phosphatase non-receptor type 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN21, protein tyrosine phosphatase non-receptor type 21
  • Synonyms
    PTPD1, PTPRL10
  • Links
    NCBI Gene ID: 11099
    neXtProt AC: NX_Q16825
    UniProt: Q16825

  • Chr Location
    14q31.3; chr14:88465778-88555007 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24000 NCBI Gene Model | MGI Sequence Detail 60665 C57BL/6J ±  kb
transcript NM_011877 RefSeq | MGI Sequence Detail 5697 C57BL/6  
polypeptide Q62136 UniProt | EBI | MGI Sequence Detail 1176 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
References
more
  • Summaries
    All 38
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:22513 Higashitsuji H, et al., Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. Oncogene. 1995 Jan 19;10(2):407-14
  • Latest
    J:296284 Hu L, et al., Decreased cell stiffness enhances leukemia development and progression. Leukemia. 2020 Sep;34(9):2493-2497
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory