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Zeb2 Gene Detail
Summary
  • Symbol
    Zeb2
  • Name
    zinc finger E-box binding homeobox 2
  • Synonyms
    9130203F04Rik, D130016B08Rik, mKIAA0569, SIP1, Zfhx1b, Zfx1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344407
    NCBI Gene: 24136
  • Alliance
    gene page
  • Transcription Start Sites
    111 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:44873644-45007407 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 27.31 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2051 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344407
 protein coding gene Chr2:44873523-45007407 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025718
 protein coding gene Chr2:44056916-44196466 (-)
A/J MGP_AJ_G0025694
 protein coding gene Chr2:42260012-42396027 (-)
AKR/J MGP_AKRJ_G0025664
 protein coding gene Chr2:43558731-43695197 (-)
BALB/cJ MGP_BALBcJ_G0025689
 protein coding gene Chr2:42316904-42452791 (-)
C3H/HeJ MGP_C3HHeJ_G0025450
 protein coding gene Chr2:43494810-43636053 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026135
 protein coding gene Chr2:45367130-45507531 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023541
 protein coding gene Chr2:40571029-40705451 (-)
CAST/EiJ MGP_CASTEiJ_G0024915
 protein coding gene Chr2:43545545-43685670 (-)
CBA/J MGP_CBAJ_G0025430
 protein coding gene Chr2:47088489-47230400 (-)
DBA/2J MGP_DBA2J_G0025561
 protein coding gene Chr2:41926210-42060868 (-)
FVB/NJ MGP_FVBNJ_G0025523
 protein coding gene Chr2:41736035-41873642 (-)
LP/J MGP_LPJ_G0025649
 protein coding gene Chr2:43850075-43988398 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025554
 protein coding gene Chr2:47515334-47657122 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026193
 protein coding gene Chr2:43490737-43626196 (-)
PWK/PhJ MGP_PWKPhJ_G0024656
 protein coding gene Chr2:41854883-41991609 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024461
 protein coding gene Chr2:43566339-43706280 (-)
WSB/EiJ MGP_WSBEiJ_G0024982
 protein coding gene Chr2:43680761-43817207 (-)



Homology
more
  • Human Ortholog
    ZEB2, zinc finger E-box binding homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZEB2, zinc finger E-box binding homeobox 2
  • Synonyms
    HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B
  • Links
    NCBI Gene ID: 9839
    neXtProt AC: NX_O60315
    UniProt: O60315

  • Chr Location
    2q22.3; chr2:144364364-144521057 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Zeb2 mouse models; 2 with human ZEB2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 10 genetic backgrounds
    18 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit a variety of defects at embryonic day 8.5 and die between embryonic days 9.5 and 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1634
  • Tissues
    575
  • cDNA Data
    30
  • Literature Summary
    82
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026872 Ensembl Gene Model | MGI Sequence Detail 133764 C57BL/6J ±  kb
    transcript ENSMUST00000028229 Ensembl | MGI Sequence Detail 5335 Not Applicable  
    polypeptide ENSMUSP00000028229 Ensembl | MGI Sequence Detail 1259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      20 Sequences
    • Protein Ontology
      PR:000017618 zinc finger E-box-binding homeobox 2
      (term hierarchy)
    • InterPro Domains
      IPR008598 Drought induced 19 protein type, zinc-binding domain
      IPR001356 Homeobox domain
      IPR009057 Homeobox-like domain superfamily
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
      IPR051574 Zinc finger E-box-binding homeobox
    • GlyGen
      Q9R0G7 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 40
      Primer pair 17
      Other 7

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442196, MGI:2442919
    References
    more
    • Summaries
      All 181
      Developmental Gene Expression 82
      Diseases 2
      Gene Ontology 13
      Phenotypes 77
    • Earliest
      J:56271 Verschueren K, et al., SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999 Jul 16;274(29):20489-98
    • Latest
      J:358444 Verstappe J, et al., ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states. iScience. 2024 Nov 15;27(11):111169
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory