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Ldb3 Gene Detail
Summary
  • Symbol
    Ldb3
  • Name
    LIM domain binding 3
  • Synonyms
    cypher, ZASP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344412
    NCBI Gene: 24131
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:34248560-34310639 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.83 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1827 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344412
 protein coding gene Chr14:34248560-34312276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021177
 protein coding gene Chr14:27884660-27948715 (-)
A/J MGP_AJ_G0021125
 protein coding gene Chr14:26814058-26876820 (-)
AKR/J MGP_AKRJ_G0021102
 protein coding gene Chr14:27995096-28062300 (-)
BALB/cJ MGP_BALBcJ_G0021129
 protein coding gene Chr14:26992251-27055122 (-)
C3H/HeJ MGP_C3HHeJ_G0020912
 protein coding gene Chr14:27923436-27988423 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021561
 protein coding gene Chr14:28952334-29018146 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019123
 protein coding gene Chr14:26826344-26890080 (-)
CAST/EiJ MGP_CASTEiJ_G0020437
 protein coding gene Chr14:27729603-27804980 (-)
CBA/J MGP_CBAJ_G0020878
 protein coding gene Chr14:29995935-30068885 (-)
DBA/2J MGP_DBA2J_G0021001
 protein coding gene Chr14:26844374-26906046 (-)
FVB/NJ MGP_FVBNJ_G0020985
 protein coding gene Chr14:26801304-26863892 (-)
LP/J MGP_LPJ_G0021070
 protein coding gene Chr14:28216227-28277898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021011
 protein coding gene Chr14:29143597-29208519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021594
 protein coding gene Chr14:27838799-27903794 (-)
PWK/PhJ MGP_PWKPhJ_G0020185
 protein coding gene Chr14:26332595-26394943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020009
 protein coding gene Chr14:27440593-27507172 (-)
WSB/EiJ MGP_WSBEiJ_G0020492
 protein coding gene Chr14:27885767-27949487 (-)



Homology
more
  • Human Ortholog
    LDB3, LIM domain binding 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDB3, LIM domain binding 3
  • Synonyms
    CMD1C, CMH24, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LVNC3, MFM4, ORACLE, PDLIM6, ZASP
  • Links
    NCBI Gene ID: 11155
    neXtProt AC: NX_O75112
    UniProt: O75112

  • Chr Location
    10q23.2; chr10:86666785-86736072 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ldb3 mouse models; 4 with human LDB3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 7 alleles in 5 genetic backgrounds
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality within a few days after birth from muscle abnormalities. Mutant mice exhibit myopathy, dysphagia, heart vascular congestion, dilated heart ventricles, cyanosis, and respiratory distress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1032
  • Tissues
    221
  • cDNA Data
    80
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021798 Ensembl Gene Model | MGI Sequence Detail 62080 C57BL/6J ±  kb
    transcript ENSMUST00000022327 Ensembl | MGI Sequence Detail 5119 Not Applicable  
    polypeptide ENSMUSP00000022327 Ensembl | MGI Sequence Detail 723 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 81
      Primer pair 7
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2145842
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 24
      Diseases 2
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:55277 Faulkner G, et al., ZASP: a new Z-band alternatively spliced PDZ-motif protein. J Cell Biol. 1999 Jul 26;146(2):465-75
    • Latest
      J:357928 Piasecka A, et al., MBNL splicing factors regulate the microtranscriptome of skeletal muscles. Nucleic Acids Res. 2024 Oct 28;52(19):12055-12073
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory