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Pglyrp1 Gene Detail
Summary
  • Symbol
    Pglyrp1
  • Name
    peptidoglycan recognition protein 1
  • Synonyms
    peptidoglycan recognition protein, PGRP-S, Tag7, Tasg7, Tnfsf3l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345092
    NCBI Gene: 21946
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18618615-18624363 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.38 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345092
 protein coding gene Chr7:18605256-18624384 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031746
 protein coding gene Chr7:16794739-16817711 (+)
A/J MGP_AJ_G0031722
 protein coding gene Chr7:16509307-16526816 (+)
AKR/J MGP_AKRJ_G0031648
 protein coding gene Chr7:16957547-16975252 (+)
BALB/cJ MGP_BALBcJ_G0031727
 protein coding gene Chr7:16692592-16710291 (+)
C3H/HeJ MGP_C3HHeJ_G0031449
 protein coding gene Chr7:17200017-17220151 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032193
 protein coding gene Chr7:17702861-17708632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029259
 protein coding gene Chr7:18162163-18175833 (+)
CAST/EiJ MGP_CASTEiJ_G0030793
 protein coding gene Chr7:13613022-13632163 (+)
CBA/J MGP_CBAJ_G0031411
 protein coding gene Chr7:18302811-18327149 (+)
DBA/2J MGP_DBA2J_G0031566
 protein coding gene Chr7:16444215-16461586 (+)
FVB/NJ MGP_FVBNJ_G0031518
 protein coding gene Chr7:16299575-16319273 (+)
LP/J MGP_LPJ_G0031649
 protein coding gene Chr7:17153219-17172226 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031554
 protein coding gene Chr7:18189949-18209024 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032221
 protein coding gene Chr7:16577044-16582800 (+)
PWK/PhJ MGP_PWKPhJ_G0030517
 protein coding gene Chr7:13522976-13541957 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030343
 protein coding gene Chr7:11234153-11256397 (+)
WSB/EiJ MGP_WSBEiJ_G0030892
 protein coding gene Chr7:16752843-16774176 (+)



Homology
more
  • Human Ortholog
    PGLYRP1, peptidoglycan recognition protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGLYRP1, peptidoglycan recognition protein 1
  • Synonyms
    PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L
  • Links
    NCBI Gene ID: 8993
    neXtProt AC: NX_O75594
    UniProt: O75594

  • Chr Location
    19q13.32; chr19:46019153-46023053 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show a defect in neutrophil killing and increased susceptibility to infection with non-pathogenic gram-positive bacteria or DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    111
  • cDNA Data
    54
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21946 NCBI Gene Model | MGI Sequence Detail 5749 C57BL/6J ±  kb
    transcript NM_009402 RefSeq | MGI Sequence Detail 681 C57BL/6  
    polypeptide O88593 UniProt | EBI | MGI Sequence Detail 182 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000012610 peptidoglycan recognition protein 1
      (term hierarchy)
    • InterPro Domains
      IPR002502 N-acetylmuramoyl-L-alanine amidase domain
      IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
      IPR015510 Peptidoglycan recognition protein
      IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
      IPR017331 Peptidoglycan recognition protein, PGRP-S
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 1
      cDNA 54
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35884, MGI:107415, MGI:1306810
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:33630 Kustikova OS, et al., [Cloning of the tag7 gene expressed in metastatic mouse tumors]. Genetika. 1996 May;32(5):621-8
    • Latest
      J:349565 Schnell A, et al., Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation. Nat Immunol. 2023 Nov;24(11):1908-1920
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory