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Pde10a Gene Detail
Summary
  • Symbol
    Pde10a
  • Name
    phosphodiesterase 10A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345143
    NCBI Gene: 23984
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:8744204-9205480 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10623 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345143
 protein coding gene Chr17:8742719-9205480 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023136
 protein coding gene Chr17:6004340-6486175 (+)
A/J MGP_AJ_G0023104
 protein coding gene Chr17:6023107-6490100 (+)
AKR/J MGP_AKRJ_G0023068
 protein coding gene Chr17:5714589-6189492 (+)
BALB/cJ MGP_BALBcJ_G0023104
 protein coding gene Chr17:5818988-6272278 (+)
C3H/HeJ MGP_C3HHeJ_G0022867
 protein coding gene Chr17:5978681-6454807 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023547
 protein coding gene Chr17:6293023-6785151 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021060
 protein coding gene Chr17:7899206-8345966 (-)
CAST/EiJ MGP_CASTEiJ_G0022381
 protein coding gene Chr17:5958670-6458366 (+)
CBA/J MGP_CBAJ_G0022839
 protein coding gene Chr17:6508787-7037603 (+)
DBA/2J MGP_DBA2J_G0022972
 protein coding gene Chr17:5687664-6146999 (+)
FVB/NJ MGP_FVBNJ_G0022941
 protein coding gene Chr17:5616700-6076418 (+)
LP/J MGP_LPJ_G0023043
 protein coding gene Chr17:5830152-6314579 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022961
 protein coding gene Chr17:6239274-6735128 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023573
 protein coding gene Chr17:5996595-6484357 (+)
PWK/PhJ MGP_PWKPhJ_G0022129
 protein coding gene Chr17:5321661-5792823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021959
 protein coding gene Chr17:5263668-5738864 (+)
WSB/EiJ MGP_WSBEiJ_G0022438
 protein coding gene Chr17:6297598-6779504 (+)



Homology
more
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE10A, phosphodiesterase 10A
  • Synonyms
    ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19
  • Links
    NCBI Gene ID: 10846
    neXtProt AC: NX_Q9Y233
    UniProt: Q9Y233

  • Chr Location
    6q27; chr6:165327287-165988117 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 6 genetic backgrounds
    381 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased exploratory behavior, hypoactivity, and a delay in the acquisition of conditioned avoidance behavior. A hypomorphic allele results in increased social behavior. Mice homozygous for a knock-out allele exhibit resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    962
  • Tissues
    130
  • cDNA Data
    45
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023868 Ensembl Gene Model | MGI Sequence Detail 461277 C57BL/6J ±  kb
    transcript ENSMUST00000115724 Ensembl | MGI Sequence Detail 3611 Not Applicable  
    polypeptide ENSMUSP00000111389 Ensembl | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012463 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
      (term hierarchy)
    • EC
      3.1.4.-, 3.1.4.17
    • InterPro Domains
      IPR023088 3'5'-cyclic nucleotide phosphodiesterase
      IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
      IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
      IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
      IPR003018 GAF domain
      IPR029016 GAF-like domain superfamily
      IPR003607 HD/PDEase domain
    • GlyGen
      Q8CA95 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 46
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 428
      Developmental Gene Expression 7
      Diseases 6
      Gene Ontology 14
      Phenotypes 381
    • Earliest
      J:7073 Washburn LL, et al., Sex reversal in XY mice caused by dominant mutation on chromosome 17. Nature. 1983 May 26;303(5915):338-40
    • Latest
      J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory