Akt3 MGI Mouse Gene Detail - MGI:1345147 - thymoma viral proto-oncogene 3

Symbol

Akt3
Name

thymoma viral proto-oncogene 3
Synonyms

D930002M15Rik, Nmf350, PKB gamma

Feature Type

protein coding gene
IDs

MGI:1345147
NCBI Gene: 23797
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr1:176847639-177085769 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 82.66 cM, cytoband H4-H6
Mapping Data

4 experiments

SNPs within 2kb

3469 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345147	protein coding gene	Chr1:176847639-177091688 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016847	protein coding gene	Chr1:183176436-183423409 (-)
A/J	MGP_AJ_G0016826	protein coding gene	Chr1:175787463-176033472 (-)
AKR/J	MGP_AKRJ_G0016792	protein coding gene	Chr1:181048260-181296144 (-)
BALB/cJ	MGP_BALBcJ_G0016783	protein coding gene	Chr1:176315226-176554560 (-)
C3H/HeJ	MGP_C3HHeJ_G0016609	protein coding gene	Chr1:181654999-181900894 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017248	protein coding gene	Chr1:189210189-189458695 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014954	protein coding gene	Chr1:167072951-167310088 (-)
CAST/EiJ	MGP_CASTEiJ_G0016190	protein coding gene	Chr1:181033347-181276024 (-)
CBA/J	MGP_CBAJ_G0016582	protein coding gene	Chr1:196091733-196353993 (-)
DBA/2J	MGP_DBA2J_G0016688	protein coding gene	Chr1:174653114-174893232 (-)
FVB/NJ	MGP_FVBNJ_G0016685	protein coding gene	Chr1:172742225-172980152 (-)
LP/J	MGP_LPJ_G0016763	protein coding gene	Chr1:184368124-184603245 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016716	protein coding gene	Chr1:203323401-203603481 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017284	protein coding gene	Chr1:180778812-181036339 (-)
PWK/PhJ	MGP_PWKPhJ_G0015977	protein coding gene	Chr1:173730799-173977400 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015754	protein coding gene	Chr1:179886729-180134359 (-)
WSB/EiJ	MGP_WSBEiJ_G0016252	protein coding gene	Chr1:181012761-181254681 (-)

Human Ortholog

AKT3, AKT serine/threonine kinase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKT3, AKT serine/threonine kinase 3
Synonyms

MPPH, MPPH2, PKBG, PKB-GAMMA, PRKBG, RAC-gamma, RAC-PK-gamma, STK-2
Links

HGNC:393

NCBI Gene ID: 10000

neXtProt AC: NX_Q9Y243

UniProt: Q9Y243
Chr Location

1q43-q44; chr1:243488233-243851079 (-) GRCh38

MGI Vertebrate Homology

Akt3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AKT3
Gene Tree

Akt3

Diseases

5 with human AKT3 associations

				Human Disease	Mouse Models
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				glioblastoma IDs glioblastoma DOID:3068 DOID:3075 DOID:3080 MESH:D005909 NCI:C129295 NCI:C39750 NCI:C9094 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422
				prostate adenocarcinoma IDs prostate adenocarcinoma DOID:2526 NCI:C2919 UMLS_CUI:C0007112
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				renal cell carcinoma IDs renal cell carcinoma DOID:4450 EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 UMLS_CUI:C0007134

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 3 alleles in 5 genetic backgrounds
20 phenotypes from multigenic genotypes
58 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

3
Targeted

8
Transposon induced

1
Genomic Mutations

3 involving Akt3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size.

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All GO Annotations

61
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

945
Tissues

86
cDNA Data

11
Literature Summary

30

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN akt3a

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All Sequences

65
RefSeq

22
UniProt

3
CCDS

CCDS35799.1

Ensembl

ENSMUSG00000019699 (Evidence)
NCBI Gene

23797

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019699	Ensembl Gene Model \| MGI Sequence Detail	238131	C57BL/6J	± kb
transcript	ENSMUST00000111159	Ensembl \| MGI Sequence Detail	4906	Not Applicable
polypeptide	ENSMUSP00000106789	Ensembl \| MGI Sequence Detail	479	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003913 RAC-gamma serine/threonine-protein kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR034675 Protein kinase B gamma, catalytic domain

IPR039026 Protein Kinase B, pleckstrin homology domain

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q9WUA6 3 sites, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 12

Primer pair 2

Other 1

Microarray probesets 7

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MGI:2138357, MGI:3628555

Summaries

All 140

Developmental Gene Expression 30

Gene Ontology 16

Phenotypes 58
Earliest

J:54026 Brodbeck D, et al., A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem. 1999 Apr 2;274(14):9133-6
Latest

J:327336 Bertol JW, et al., TWIST1 interacts with beta/delta-catenins during neural tube development and regulates fate transition in cranial neural crest cells. Development. 2022 Aug 1;149(15):dev200068

TSS for Akt3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr311	Chr1:177086515-177086524 (-)	-751 bp
Tssr15441	Chr1:177086395-177086423 (-)	-640 bp
Tssr15440	Chr1:177085881-177086004 (-)	-174 bp
Tssr15439	Chr1:177085748-177085780 (-)	5 bp
Tssr15438	Chr1:177066691-177066693 (-)	19,077 bp
Tssr15437	Chr1:177034981-177034987 (-)	50,785 bp
Tssr15436	Chr1:177031470-177031479 (-)	54,294 bp
Tssr15435	Chr1:177021498-177021519 (-)	64,260 bp
Tssr15434	Chr1:176958633-176958644 (-)	127,130 bp
Tssr15433	Chr1:176898891-176898910 (-)	186,868 bp
Tssr15432	Chr1:176892050-176892071 (-)	193,708 bp
Tssr15431	Chr1:176877765-176877779 (-)	207,997 bp
Tssr15430	Chr1:176861272-176861275 (-)	224,495 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24