Pacsin2 MGI Mouse Gene Detail - MGI:1345153 - protein kinase C and casein kinase substrate in neurons 2

Symbol

Pacsin2
Name

protein kinase C and casein kinase substrate in neurons 2
Synonyms

Syndapin II

Feature Type

protein coding gene
IDs

MGI:1345153
NCBI Gene: 23970
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr15:83259812-83348800 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.40 cM
Mapping Data

2 experiments

SNPs within 2kb

1668 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345153	protein coding gene	Chr15:83259808-83348807 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022163	protein coding gene	Chr15:84073121-84169767 (-)
A/J	MGP_AJ_G0022122	protein coding gene	Chr15:80996562-81089364 (-)
AKR/J	MGP_AKRJ_G0022097	protein coding gene	Chr15:83352693-83448000 (-)
BALB/cJ	MGP_BALBcJ_G0022128	protein coding gene	Chr15:81137963-81230480 (-)
C3H/HeJ	MGP_C3HHeJ_G0021898	protein coding gene	Chr15:83313354-83404642 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022573	protein coding gene	Chr15:87316629-87419037 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020098	protein coding gene	Chr15:77372373-77462740 (-)
CAST/EiJ	MGP_CASTEiJ_G0021420	protein coding gene	Chr15:84081585-84175264 (-)
CBA/J	MGP_CBAJ_G0021865	protein coding gene	Chr15:90075039-90180163 (-)
DBA/2J	MGP_DBA2J_G0021992	protein coding gene	Chr15:80481289-80553638 (-)
FVB/NJ	MGP_FVBNJ_G0021971	protein coding gene	Chr15:79523546-79616193 (-)
LP/J	MGP_LPJ_G0022063	protein coding gene	Chr15:84247014-84340869 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021991	protein coding gene	Chr15:94988791-95083152 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022588	protein coding gene	Chr15:83356167-83447950 (-)
PWK/PhJ	MGP_PWKPhJ_G0021161	protein coding gene	Chr15:80467490-80556314 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020995	protein coding gene	Chr15:83076777-83172805 (-)
WSB/EiJ	MGP_WSBEiJ_G0021469	protein coding gene	Chr15:83856171-83949504 (-)

Human Ortholog

PACSIN2, protein kinase C and casein kinase substrate in neurons 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PACSIN2, protein kinase C and casein kinase substrate in neurons 2
Synonyms

SDPII
Links

HGNC:8571

NCBI Gene ID: 11252

neXtProt AC: NX_Q9UNF0

UniProt: Q9UNF0
Chr Location

22q13.2; chr22:42835412-43015149 (-) GRCh38

MGI Vertebrate Homology

Pacsin2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PACSIN2
Gene Tree

Pacsin2

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References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

81
Chemically induced (other)

1
Gene trapped

74
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Pacsin2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced running endurance, distance, and speed with impaired fetal cardiomyocyte electrophysiology.

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All GO Annotations

50
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

39
cDNA Data

95
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pacsin2

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All Sequences

110
RefSeq

33
UniProt

7
CCDS

CCDS27701.1

Ensembl

ENSMUSG00000016664 (Evidence)
NCBI Gene

23970

			Length	Strain/Species	Flank
genomic	23970	NCBI Gene Model \| MGI Sequence Detail	88989	C57BL/6J	± kb
transcript	NM_001411851	RefSeq \| MGI Sequence Detail	3765	C57BL/6
polypeptide	Q9WVE8	UniProt \| EBI \| MGI Sequence Detail	486	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012218 protein kinase C and casein kinase substrate in neurons protein 2

(term hierarchy)
PDB

3LLL
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR035743 PACSIN1/PACSIN2, SH3 domain

IPR037453 PACSIN2, F-BAR domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR050670 Signal Transducing Adapter Molecule
GlyGen

Q9WVE8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 95

cDNA 95

Microarray probesets 3

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MGI:2145958

Summaries

All 76

Developmental Gene Expression 5

Diseases 1

Gene Ontology 13

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pacsin2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135676	Chr15:83348796-83348815 (-)	-6 bp
Tssr135675	Chr15:83348777-83348792 (-)	15 bp
Tssr135674	Chr15:83348735-83348764 (-)	50 bp
Tssr135673	Chr15:83332184-83332193 (-)	16,611 bp
Tssr135672	Chr15:83332117-83332143 (-)	16,670 bp
Tssr135671	Chr15:83332061-83332077 (-)	16,731 bp
Tssr135670	Chr15:83317020-83317060 (-)	31,760 bp
Tssr135669	Chr15:83316995-83317014 (-)	31,795 bp
Tssr135668	Chr15:83307981-83307994 (-)	40,812 bp
Tssr135667	Chr15:83307960-83307971 (-)	40,834 bp
Tssr135666	Chr15:83307943-83307952 (-)	40,852 bp
Tssr135665	Chr15:83301117-83301119 (-)	47,682 bp
Tssr135664	Chr15:83278158-83278175 (-)	70,633 bp
Tssr135663	Chr15:83269978-83269996 (-)	78,813 bp
Tssr135662	Chr15:83261538-83261557 (-)	87,252 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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