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Adam23 Gene Detail
Summary
  • Symbol
    Adam23
  • Name
    a disintegrin and metallopeptidase domain 23
  • Synonyms
    MDC3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345162
    NCBI Gene: 23792
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:63484880-63635263 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.31 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1051 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345162
 protein coding gene Chr1:63484880-63635435 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016089
 protein coding gene Chr1:63610408-63760339 (+)
A/J MGP_AJ_G0016072
 protein coding gene Chr1:61360331-61512527 (+)
AKR/J MGP_AKRJ_G0016029
 protein coding gene Chr1:63060397-63216478 (+)
BALB/cJ MGP_BALBcJ_G0016027
 protein coding gene Chr1:61438887-61592362 (+)
C3H/HeJ MGP_C3HHeJ_G0015859
 protein coding gene Chr1:63349402-63507808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016480
 protein coding gene Chr1:66058416-66224595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014201
 protein coding gene Chr1:57457265-57607801 (+)
CAST/EiJ MGP_CASTEiJ_G0015442
 protein coding gene Chr1:62603971-62781116 (+)
CBA/J MGP_CBAJ_G0015831
 protein coding gene Chr1:68192272-68370014 (+)
DBA/2J MGP_DBA2J_G0015932
 protein coding gene Chr1:60779277-60932127 (+)
FVB/NJ MGP_FVBNJ_G0015935
 protein coding gene Chr1:60064370-60216028 (+)
LP/J MGP_LPJ_G0016004
 protein coding gene Chr1:64496583-64655621 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015955
 protein coding gene Chr1:71115558-71296368 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016527
 protein coding gene Chr1:63038615-63216606 (+)
PWK/PhJ MGP_PWKPhJ_G0015229
 protein coding gene Chr1:60146659-60305926 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015008
 protein coding gene Chr1:62546112-62712217 (+)
WSB/EiJ MGP_WSBEiJ_G0015504
 protein coding gene Chr1:62763979-62925811 (+)



Homology
more
  • Human Ortholog
    ADAM23, ADAM metallopeptidase domain 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM23, ADAM metallopeptidase domain 23
  • Synonyms
    MDC-3, MDC3
  • Links
    NCBI Gene ID: 8745
    neXtProt AC: NX_O75077
    UniProt: O75077

  • Chr Location
    2q33.3; chr2:206443532-206621127 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an insertional mutation that inactivates the gene are smaller than normal littermates, show delayed lung development, are lethal by postnatal day 14, and display severe tremor and ataxia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1008
  • Tissues
    96
  • cDNA Data
    34
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23792 NCBI Gene Model | MGI Sequence Detail 150384 C57BL/6J ±  kb
    transcript NM_011780 RefSeq | MGI Sequence Detail 6271 ZRU/MplStud  
    polypeptide Q9R1V7 UniProt | EBI | MGI Sequence Detail 829 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003719 disintegrin and metalloproteinase domain-containing protein 23
      (term hierarchy)
    • InterPro Domains
      IPR006586 ADAM, cysteine-rich domain
      IPR001762 Disintegrin domain
      IPR036436 Disintegrin domain superfamily
      IPR000742 EGF-like domain
      IPR013111 EGF-like domain, extracellular
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR002870 Peptidase M12B, propeptide
      IPR034027 Reprolysin domain, adamalysin-type
    • GlyGen
      Q9R1V7 9 sites, 9 N-linked glycans (6 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 1
      cDNA 36
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138543
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 12
      Gene Ontology 9
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345940 Miyazaki Y, et al., Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Rep. 2024 Jan 23;43(1):113634
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory