Aadat MGI Mouse Gene Detail - MGI:1345167 - aminoadipate aminotransferase

Symbol

Aadat
Name

aminoadipate aminotransferase
Synonyms

Kat2, KATII, Kyat2, mKat-2

Feature Type

protein coding gene
IDs

MGI:1345167
NCBI Gene: 23923
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr8:60958966-60998711 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 30.85 cM
Mapping Data

3 experiments

SNPs within 2kb

1070 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345167	protein coding gene	Chr8:60958877-60998711 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033629	protein coding gene	Chr8:60386496-60430151 (+)
A/J	MGP_AJ_G0033611	protein coding gene	Chr8:57823861-57864853 (+)
AKR/J	MGP_AKRJ_G0033536	protein coding gene	Chr8:59474478-59515687 (+)
BALB/cJ	MGP_BALBcJ_G0033607	protein coding gene	Chr8:58076670-58113925 (+)
C3H/HeJ	MGP_C3HHeJ_G0033317	protein coding gene	Chr8:60153640-60193463 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034124	protein coding gene	Chr8:62694548-62743370 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031072	protein coding gene	Chr8:53097783-53131157 (+)
CAST/EiJ	MGP_CASTEiJ_G0032642	protein coding gene	Chr8:59561032-59605000 (+)
CBA/J	MGP_CBAJ_G0033295	protein coding gene	Chr8:64985485-65024581 (+)
DBA/2J	MGP_DBA2J_G0033449	protein coding gene	Chr8:57583733-57618917 (+)
FVB/NJ	MGP_FVBNJ_G0033390	protein coding gene	Chr8:56907263-56942591 (+)
LP/J	MGP_LPJ_G0033537	protein coding gene	Chr8:60357163-60400989 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033434	protein coding gene	Chr8:67111706-67150845 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034142	protein coding gene	Chr8:59728813-59776785 (+)
PWK/PhJ	MGP_PWKPhJ_G0032351	protein coding gene	Chr8:56894928-56929866 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032187	protein coding gene	Chr8:58705961-58749996 (+)
WSB/EiJ	MGP_WSBEiJ_G0032759	protein coding gene	Chr8:60075147-60113953 (+)

Human Ortholog

AADAT, aminoadipate aminotransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AADAT, aminoadipate aminotransferase
Synonyms

KAT2, KATII, KYAT2
Links

HGNC:17929

NCBI Gene ID: 51166

neXtProt AC: NX_Q8N5Z0

UniProt: Q8N5Z0
Chr Location

4q33

MGI Vertebrate Homology

Aadat stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AADAT
Gene Tree

Aadat

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Aadat
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

Homozygous null mice are viable and display earlier eye opening and development of air righting and open field crossing responses, and transient hyperactivity and neuronal abnormalities.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

922
Tissues

150
cDNA Data

74
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aadat

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS22320.1

Ensembl

ENSMUSG00000057228 (Evidence)
NCBI Gene

23923

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057228	Ensembl Gene Model \| MGI Sequence Detail	39746	C57BL/6J	± kb
transcript	ENSMUST00000209338	Ensembl \| MGI Sequence Detail	1597	Not Applicable
polypeptide	ENSMUSP00000148060	Ensembl \| MGI Sequence Detail	432	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003525 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

(term hierarchy)
EC

2.6.1.39, 2.6.1.4, 2.6.1.63, 2.6.1.7, 2.6.1.73
InterPro Domains

IPR004839 Aminotransferase, class I/classII

IPR050859 Class-I PLP-Dependent Aminotransferase

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain

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All nucleic 76

cDNA 74

Primer pair 2

Microarray probesets 3

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MGI:2142647

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 11
Earliest

J:56834 Yu P, et al., Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. Mamm Genome. 1999 Sep;10(9):845-52
Latest

J:258106 Sathyasaikumar KV, et al., Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. Neuroscience. 2017 Dec 26;367:85-97

TSS for Aadat:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77446	Chr8:60958931-60958944 (+)	-28 bp
Tssr77447	Chr8:60959143-60959159 (+)	185 bp
Tssr2573	Chr8:60959211-60959218 (+)	249 bp
Tssr77448	Chr8:60961758-60961762 (+)	2,794 bp
Tssr77449	Chr8:60969048-60969075 (+)	10,096 bp
Tssr77450	Chr8:60971272-60971276 (+)	12,308 bp
Tssr2574	Chr8:60975486-60975504 (+)	16,529 bp
Tssr77451	Chr8:60975718-60975743 (+)	16,765 bp
Tssr77452	Chr8:60977239-60977246 (+)	18,277 bp
Tssr2575	Chr8:60977269-60977275 (+)	18,306 bp
Tssr77453	Chr8:60977352-60977358 (+)	18,389 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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