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Rhof Gene Detail
Summary
  • Symbol
    Rhof
  • Name
    ras homolog family member F (in filopodia)
  • Synonyms
    Arhf, Ifld1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345629
    NCBI Gene: 23912
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123256243-123270692 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.77 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345629
 protein coding gene Chr5:123241107-123270755 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030064
 protein coding gene Chr5:126786730-126819286 (-)
A/J MGP_AJ_G0030029
 protein coding gene Chr5:121536874-121566149 (-)
AKR/J MGP_AKRJ_G0029965
 protein coding gene Chr5:125443968-125481762 (-)
BALB/cJ MGP_BALBcJ_G0030040
 protein coding gene Chr5:122870290-122900525 (-)
C3H/HeJ MGP_C3HHeJ_G0029757
 protein coding gene Chr5:126070540-126099637 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030493
 protein coding gene Chr5:131678573-131712736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027719
 protein coding gene Chr5:116119825-116149449 (-)
CAST/EiJ MGP_CASTEiJ_G0029166
 protein coding gene Chr5:125177542-125210048 (-)
CBA/J MGP_CBAJ_G0029727
 protein coding gene Chr5:136842454-136873529 (-)
DBA/2J MGP_DBA2J_G0029877
 protein coding gene Chr5:121582967-121612163 (-)
FVB/NJ MGP_FVBNJ_G0029833
 protein coding gene Chr5:120584040-120613510 (-)
LP/J MGP_LPJ_G0029966
 protein coding gene Chr5:127321060-127354678 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029864
 protein coding gene Chr5:140526378-140558204 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030534
 protein coding gene Chr5:125046497-125077025 (-)
PWK/PhJ MGP_PWKPhJ_G0028880
 protein coding gene Chr5:120369204-120399848 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028717
 protein coding gene Chr5:122745335-122774372 (-)
WSB/EiJ MGP_WSBEiJ_G0029241
 protein coding gene Chr5:125715074-125745641 (-)



Homology
more
  • Human Ortholog
    RHOF, ras homolog family member F, filopodia associated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOF, ras homolog family member F, filopodia associated
  • Synonyms
    ARHF, RIF
  • Links
    NCBI Gene ID: 54509
    neXtProt AC: NX_Q9HBH0
    UniProt: Q9HBH0

  • Chr Location
    12q24.31; chr12:121777754-121803403 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit macrothrombocytopenia without an effect on filopodia generation. Homozygous knockout also leads to the reduction of the number of B cells in the spleen marginal zone.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23912 NCBI Gene Model | MGI Sequence Detail 14450 C57BL/6J ±  kb
    transcript NM_175092 RefSeq | MGI Sequence Detail 2143 C57BL/6  
    polypeptide Q8BYP3 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 22

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2140981, MGI:2141105
    References
    more
    • Summaries
      All 36
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:274905 Shaverdashvili K, et al., KLF4 activates NFkappaB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. PLoS One. 2019;14(4):e0215746
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory