Trib3 MGI Mouse Gene Detail - MGI:1345675

Symbol

Trib3
Name

tribbles pseudokinase 3
Synonyms

Ifld2, Nipk, SKIP3, Trb3

Feature Type

protein coding gene
IDs

MGI:1345675
NCBI Gene: 228775
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:152179342-152185952 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.83 cM
Mapping Data

3 experiments

SNPs within 2kb

228 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345675	protein coding gene	Chr2:152179342-152185980 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026656	protein coding gene	Chr2:156866449-156872956 (-)
A/J	MGP_AJ_G0026622	protein coding gene	Chr2:150621132-150627748 (-)
AKR/J	MGP_AKRJ_G0026592	protein coding gene	Chr2:155015417-155022034 (-)
BALB/cJ	MGP_BALBcJ_G0026631	protein coding gene	Chr2:150928823-150936078 (-)
C3H/HeJ	MGP_C3HHeJ_G0026374	protein coding gene	Chr2:155399314-155405862 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027080	protein coding gene	Chr2:161450457-161457704 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024451	protein coding gene	Chr2:144214090-144221082 (-)
CAST/EiJ	MGP_CASTEiJ_G0025835	protein coding gene	Chr2:155636116-155643606 (-)
CBA/J	MGP_CBAJ_G0026352	protein coding gene	Chr2:167362547-167369162 (-)
DBA/2J	MGP_DBA2J_G0026488	protein coding gene	Chr2:149836898-149843523 (-)
FVB/NJ	MGP_FVBNJ_G0026453	protein coding gene	Chr2:148278020-148284808 (-)
LP/J	MGP_LPJ_G0026592	protein coding gene	Chr2:157034215-157040732 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026475	protein coding gene	Chr2:171471106-171479208 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027135	protein coding gene	Chr2:154893336-154901595 (-)
PWK/PhJ	MGP_PWKPhJ_G0025569	protein coding gene	Chr2:149355380-149362241 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025372	protein coding gene	Chr2:153729117-153735647 (-)
WSB/EiJ	MGP_WSBEiJ_G0025905	protein coding gene	Chr2:155820679-155827240 (-)

Human Ortholog

TRIB3, tribbles pseudokinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIB3, tribbles pseudokinase 3
Synonyms

C20orf97, NIPK, SINK, SKIP3, TRB3
Links

HGNC:16228

NCBI Gene ID: 57761

neXtProt AC: NX_Q96RU7

UniProt: Q96RU7
Chr Location

20p13; chr20:362835-397559 (+) GRCh38

MGI Vertebrate Homology

Trib3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIB3
Gene Tree

Trib3

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Phenotype Summary

9 phenotypes from 4 alleles in 3 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

8
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

2 involving Trib3
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants may display hypoactivity, decreased blood pressure and abnormal digit morphology or abnormal mast cell physiology.

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All GO Annotations

42
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

65
cDNA Data

43
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN trib3

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All Sequences

54
RefSeq

2
UniProt

2
CCDS

CCDS16881.1

Ensembl

ENSMUSG00000032715 (Evidence)
NCBI Gene

228775

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032715	Ensembl Gene Model \| MGI Sequence Detail	6611	C57BL/6J	± kb
transcript	ENSMUST00000040312	Ensembl \| MGI Sequence Detail	2026	Not Applicable
polypeptide	ENSMUSP00000041747	Ensembl \| MGI Sequence Detail	354	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016640 tribbles homolog 3

(term hierarchy)
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR024104 Pseudokinase tribbles family/serine-threonine-protein kinase 40

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All nucleic 49

cDNA 43

Primer pair 6

Microarray probesets 3

Summaries

All 103

Developmental Gene Expression 22

Gene Ontology 12

Phenotypes 32
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;

TSS for Trib3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26800	Chr2:152185996-152186005 (-)	-49 bp
Tssr26799	Chr2:152185963-152185988 (-)	-24 bp
Tssr26798	Chr2:152185929-152185953 (-)	11 bp
Tssr26797	Chr2:152185902-152185927 (-)	37 bp
Tssr26796	Chr2:152185884-152185891 (-)	64 bp
Tssr26795	Chr2:152185862-152185871 (-)	85 bp
Tssr26794	Chr2:152185829-152185842 (-)	116 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24