Ptpa MGI Mouse Gene Detail - MGI:1346006 - protein phosphatase 2 protein activator

Symbol

Ptpa
Name

protein phosphatase 2 protein activator
Synonyms

2610042B21Rik, MGC:60706, MGC:7129, Ppp2r4

Feature Type

protein coding gene
IDs

MGI:1346006
NCBI Gene: 110854
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr2:30306062-30337819 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.71 cM
Mapping Data

2 experiments

SNPs within 2kb

809 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346006	protein coding gene	Chr2:30306051-30337819 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025569	protein coding gene	Chr2:28642426-28676061 (+)
A/J	MGP_AJ_G0025547	protein coding gene	Chr2:27502875-27534332 (+)
AKR/J	MGP_AKRJ_G0025516	protein coding gene	Chr2:28436189-28471527 (+)
BALB/cJ	MGP_BALBcJ_G0025543	protein coding gene	Chr2:27628824-27661456 (+)
C3H/HeJ	MGP_C3HHeJ_G0025304	protein coding gene	Chr2:28367032-28402842 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025988	protein coding gene	Chr2:29582059-29619986 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023396	protein coding gene	Chr2:26278301-26310566 (+)
CAST/EiJ	MGP_CASTEiJ_G0024766	protein coding gene	Chr2:28266424-28301531 (+)
CBA/J	MGP_CBAJ_G0025281	protein coding gene	Chr2:30587227-30631961 (+)
DBA/2J	MGP_DBA2J_G0025414	protein coding gene	Chr2:27291342-27322787 (+)
FVB/NJ	MGP_FVBNJ_G0025377	protein coding gene	Chr2:27111341-27143159 (+)
LP/J	MGP_LPJ_G0025500	protein coding gene	Chr2:28549758-28585180 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025407	protein coding gene	Chr2:30468960-30502705 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026046	protein coding gene	Chr2:28350796-28383573 (+)
PWK/PhJ	MGP_PWKPhJ_G0024513	protein coding gene	Chr2:27131828-27166828 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024313	protein coding gene	Chr2:28471775-28505786 (+)
WSB/EiJ	MGP_WSBEiJ_G0024834	protein coding gene	Chr2:28481539-28519202 (+)

Human Ortholog

PTPA, protein phosphatase 2 phosphatase activator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPA, protein phosphatase 2 phosphatase activator
Synonyms

PARK25, PP2A, PPP2R4, PR53
Links

HGNC:9308

NCBI Gene ID: 5524

neXtProt AC: NX_Q15257

UniProt: Q15257
Chr Location

9q34.11; chr9:129110950-129148946 (+) GRCh38

MGI Vertebrate Homology

Ptpa stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPA
Protein SuperFamily

Phstyr_phstse_ac
Gene Tree

Ptpa

Diseases

1 with human PTPA associations

				Human Disease	Mouse Models
				Parkinson's disease 25 IDs Parkinson's disease 25 DOID:0070486 OMIM:620482

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotype references

All Mutations and Alleles

90
Gene trapped

86
Targeted

4
Incidental Mutations

CvDC
Find Mice (IMSR)

91 strains or lines available

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All GO Annotations

37
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

4
cDNA Data

245
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpa

ZFIN ptpa

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All Sequences

120
RefSeq

8
UniProt

8
CCDS

CCDS15883.1

Ensembl

ENSMUSG00000039515 (Evidence)
NCBI Gene

110854

			Length	Strain/Species	Flank
genomic	110854	NCBI Gene Model \| MGI Sequence Detail	31758	C57BL/6J	± kb
transcript	NM_001362733	RefSeq \| MGI Sequence Detail	2583	ZRU/MplStud
polypeptide	P58389	UniProt \| EBI \| MGI Sequence Detail	323	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000013142 serine/threonine-protein phosphatase 2A regulatory subunit B'

(term hierarchy)
EC

5.2.1.8
InterPro Domains

IPR043170 Phosphotyrosyl phosphatase activator, C-terminal lid domain

IPR004327 Phosphotyrosyl phosphatase activator, PTPA

IPR037218 PTPA superfamily
GlyGen

P58389 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 245

cDNA 245

Microarray probesets 4

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MGI:1923815, MGI:2139462, MGI:2139539

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 15
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ptpa:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17115	Chr2:30305630-30305695 (+)	-399 bp
Tssr17116	Chr2:30306043-30306089 (+)	4 bp
Tssr17117	Chr2:30306092-30306102 (+)	35 bp
Tssr17118	Chr2:30306108-30306159 (+)	72 bp
Tssr17119	Chr2:30306199-30306233 (+)	154 bp
Tssr17120	Chr2:30320054-30320059 (+)	13,995 bp
Tssr17121	Chr2:30329519-30329546 (+)	23,471 bp
Tssr17122	Chr2:30331843-30331848 (+)	25,784 bp
Tssr17123	Chr2:30331931-30331961 (+)	25,884 bp
Tssr17124	Chr2:30331990-30332016 (+)	25,941 bp
Tssr17125	Chr2:30332075-30332090 (+)	26,021 bp
Tssr17126	Chr2:30335646-30335659 (+)	29,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24