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Arhgef28 Gene Detail
Summary
  • Symbol
    Arhgef28
  • Name
    Rho guanine nucleotide exchange factor 28
  • Synonyms
    9230110L08Rik, D13Bwg1089e, p190RhoGEF, Rgnef, RhoGEF, Rho specific exchange factor, RIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346016
    NCBI Gene: 110596
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:98035977-98342947 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 51.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9366 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346016
 protein coding gene Chr13:98035105-98343183 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020861
 protein coding gene Chr13:99574915-99901639 (-)
A/J MGP_AJ_G0020815
 protein coding gene Chr13:95797505-96098713 (-)
AKR/J MGP_AKRJ_G0020789
 protein coding gene Chr13:98721388-99033910 (-)
BALB/cJ MGP_BALBcJ_G0020813
 protein coding gene Chr13:96491201-96799366 (-)
C3H/HeJ MGP_C3HHeJ_G0020604
 protein coding gene Chr13:98451773-98769868 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021247
 protein coding gene Chr13:102573375-102915233 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018817
 protein coding gene Chr13:91546427-91843353 (-)
CAST/EiJ MGP_CASTEiJ_G0020123
 protein coding gene Chr13:97803080-98132403 (-)
CBA/J MGP_CBAJ_G0020564
 protein coding gene Chr13:106680623-107017879 (-)
DBA/2J MGP_DBA2J_G0020689
 protein coding gene Chr13:95562775-95872437 (-)
FVB/NJ MGP_FVBNJ_G0020670
 protein coding gene Chr13:94320221-94627621 (-)
LP/J MGP_LPJ_G0020764
 protein coding gene Chr13:99683815-100008725 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020698
 protein coding gene Chr13:106976528-107326379 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021288
 protein coding gene Chr13:98161789-98481066 (-)
PWK/PhJ MGP_PWKPhJ_G0019876
 protein coding gene Chr13:94361899-94667654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019699
 protein coding gene Chr13:94432342-94753464 (-)
WSB/EiJ MGP_WSBEiJ_G0020180
 protein coding gene Chr13:98611555-98929387 (-)



Homology
more
  • Human Ortholog
    ARHGEF28, Rho guanine nucleotide exchange factor 28
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF28, Rho guanine nucleotide exchange factor 28
  • Synonyms
    p190RHOGEF, RGNEF, RIP2
  • Links
    NCBI Gene ID: 64283
    neXtProt AC: NX_Q8N1W1
    UniProt: Q8N1W1

  • Chr Location
    5q13.2; chr5:73626158-73941993 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born at lower than expected Mendelian ratios and exhibit a reduction in overall size that becomes negligible by 8 weeks of age. Mouse embryonic fibroblasts display defects in cell migration and focal adhesion formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    23
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021662 Ensembl Gene Model | MGI Sequence Detail 306971 C57BL/6J ±  kb
    transcript ENSMUST00000109426 Ensembl | MGI Sequence Detail 5387 Not Applicable  
    polypeptide ENSMUSP00000105053 Ensembl | MGI Sequence Detail 1700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34027, MGI:106335, MGI:1349443, MGI:1925160, MGI:2145208
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory