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Slco2a1 Gene Detail
Summary
  • Symbol
    Slco2a1
  • Name
    solute carrier organic anion transporter family, member 2a1
  • Synonyms
    2310021C19Rik, mPgt, Pgt, Slc21a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346021
    NCBI Gene: 24059
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:102885686-102973201 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 54.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2792 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346021
 protein coding gene Chr9:102865911-102973201 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035192
 protein coding gene Chr9:104584534-104698636 (+)
A/J MGP_AJ_G0035172
 protein coding gene Chr9:100821918-100929021 (+)
AKR/J MGP_AKRJ_G0035104
 protein coding gene Chr9:103316111-103428106 (+)
BALB/cJ MGP_BALBcJ_G0035165
 protein coding gene Chr9:100533508-100645630 (+)
C3H/HeJ MGP_C3HHeJ_G0034875
 protein coding gene Chr9:103711073-103820664 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035685
 protein coding gene Chr9:107494325-107609556 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032584
 protein coding gene Chr9:98411486-98517730 (+)
CAST/EiJ MGP_CASTEiJ_G0034187
 protein coding gene Chr9:103545867-103661221 (+)
CBA/J MGP_CBAJ_G0034844
 protein coding gene Chr9:111247747-111363260 (+)
DBA/2J MGP_DBA2J_G0035005
 protein coding gene Chr9:100315965-100424048 (+)
FVB/NJ MGP_FVBNJ_G0034953
 protein coding gene Chr9:99111338-99221037 (+)
LP/J MGP_LPJ_G0035081
 protein coding gene Chr9:104790189-104902891 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034992
 protein coding gene Chr9:113059146-113172710 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035707
 protein coding gene Chr9:103561761-103672418 (+)
PWK/PhJ MGP_PWKPhJ_G0033894
 protein coding gene Chr9:100565607-100680233 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033729
 protein coding gene Chr9:103613367-103724151 (+)
WSB/EiJ MGP_WSBEiJ_G0034307
 protein coding gene Chr9:103449794-103561830 (+)



Homology
more
  • Human Ortholog
    SLCO2A1, solute carrier organic anion transporter family member 2A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLCO2A1, solute carrier organic anion transporter family member 2A1
  • Synonyms
    MATR1, OATP2A1, PGT, PHOAD, PHOAR2, SLC21A2
  • Links
    NCBI Gene ID: 6578
    neXtProt AC: NX_Q92959
    UniProt: Q92959

  • Chr Location
    3q22.1-q22.2; chr3:133932701-134052184 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLCO2A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit preinatel or early psotnatal lethality due to a patent ductus arteriosus and abnormal protaglandin metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    172
  • cDNA Data
    16
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24059 NCBI Gene Model | MGI Sequence Detail 87516 C57BL/6J ±  kb
    transcript NM_033314 RefSeq | MGI Sequence Detail 4451 ZRU/MplStud  
    polypeptide Q9EPT5 UniProt | EBI | MGI Sequence Detail 643 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915306
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:57568 Pucci ML, et al., Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am J Physiol. 1999 Sep;277(3 Pt 2):R734-41
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory