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Pin1 Gene Detail
Summary
  • Symbol
    Pin1
  • Name
    peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1
  • Synonyms
    0610025L01Rik, D9Bwg1161e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346036
    NCBI Gene: 23988
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20563335-20575008 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    341 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346036
 protein coding gene Chr9:20563335-20577880 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034424
 protein coding gene Chr9:17796402-17812954 (+)
A/J MGP_AJ_G0034402
 protein coding gene Chr9:17515046-17530070 (+)
AKR/J MGP_AKRJ_G0034329
 protein coding gene Chr9:17834163-17850512 (+)
BALB/cJ MGP_BALBcJ_G0034393
 protein coding gene Chr9:17418990-17433857 (+)
C3H/HeJ MGP_C3HHeJ_G0034105
 protein coding gene Chr9:18146282-18160598 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034914
 protein coding gene Chr9:18516452-18531440 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031844
 protein coding gene Chr9:16651812-16665658 (+)
CAST/EiJ MGP_CASTEiJ_G0033428
 protein coding gene Chr9:17956097-17973799 (+)
CBA/J MGP_CBAJ_G0034078
 protein coding gene Chr9:19231933-19246393 (+)
DBA/2J MGP_DBA2J_G0034237
 protein coding gene Chr9:17511417-17525863 (+)
FVB/NJ MGP_FVBNJ_G0034180
 protein coding gene Chr9:17011126-17026127 (+)
LP/J MGP_LPJ_G0034322
 protein coding gene Chr9:17982407-17998070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034223
 protein coding gene Chr9:20867859-20885686 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034934
 protein coding gene Chr9:17779586-17794028 (+)
PWK/PhJ MGP_PWKPhJ_G0033134
 protein coding gene Chr9:17472689-17487565 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032968
 protein coding gene Chr9:17818276-17836447 (+)
WSB/EiJ MGP_WSBEiJ_G0033543
 protein coding gene Chr9:17509882-17524572 (+)



Homology
more
  • Human Ortholog
    PIN1, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIN1, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • Synonyms
    DOD, UBL5
  • Links
    NCBI Gene ID: 5300
    neXtProt AC: NX_Q13526
    UniProt: Q13526

  • Chr Location
    19p13.2; chr19:9835257-9849689 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pin1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes exhibit cell-proliferation abnormalities, including a late-developing reduction in body weight and progressive testicular and retinal atrophies. Mutant females fail to undergo mammary epithelial duct expansion associated with pregnancy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    77
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    11
  • cDNA Data
    111
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23988 NCBI Gene Model | MGI Sequence Detail 11674 C57BL/6J ±  kb
    transcript NM_023371 RefSeq | MGI Sequence Detail 948 ZRU/MplStud  
    polypeptide Q9QUR7 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • EC
      5.2.1.8
    • InterPro Domains
      IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
      IPR051370 Peptidyl-prolyl cis-trans isomerase Pin1
      IPR000297 Peptidyl-prolyl cis-trans isomerase, PpiC-type
      IPR023058 Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
      IPR001202 WW domain
      IPR036020 WW domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 111
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34105, MGI:106411, MGI:1914920
    References
    more
    • Summaries
      All 166
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 20
      Phenotypes 88
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:347733 Nakatsu Y, et al., Prolyl isomerase Pin1 in skeletal muscles contributes to systemic energy metabolism and exercise capacity through regulating SERCA activity. Biochem Biophys Res Commun. 2024 Apr 24;715:150001
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory