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Kel Gene Detail
Summary
  • Symbol
    Kel
  • Name
    Kell blood group
  • Synonyms
    CD238
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346053
    NCBI Gene: 23925
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41663263-41681268 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    502 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346053
 protein coding gene Chr6:41663263-41681273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030634
 protein coding gene Chr6:40203362-40221887 (-)
A/J MGP_AJ_G0030607
 protein coding gene Chr6:38455608-38473102 (-)
AKR/J MGP_AKRJ_G0030532
 protein coding gene Chr6:39700407-39717743 (-)
BALB/cJ MGP_BALBcJ_G0030617
 protein coding gene Chr6:38661027-38678267 (-)
C3H/HeJ MGP_C3HHeJ_G0030330
 protein coding gene Chr6:39724022-39742450 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031071
 protein coding gene Chr6:41224423-41243196 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028278
 protein coding gene Chr6:36229641-36247176 (-)
CAST/EiJ MGP_CASTEiJ_G0029734
 protein coding gene Chr6:39532520-39550511 (-)
CBA/J MGP_CBAJ_G0030306
 protein coding gene Chr6:42923638-42942517 (-)
DBA/2J MGP_DBA2J_G0030450
 protein coding gene Chr6:38284218-38301932 (-)
FVB/NJ MGP_FVBNJ_G0030406
 protein coding gene Chr6:38006240-38024196 (-)
LP/J MGP_LPJ_G0030538
 protein coding gene Chr6:40205762-40226144 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030440
 protein coding gene Chr6:45155949-45174304 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031101
 protein coding gene Chr6:39671830-39689929 (-)
PWK/PhJ MGP_PWKPhJ_G0029446
 protein coding gene Chr6:37905932-37923889 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029283
 protein coding gene Chr6:39286437-39308403 (-)
WSB/EiJ MGP_WSBEiJ_G0029810
 protein coding gene Chr6:39584327-39602660 (-)



Homology
more
  • Human Ortholog
    KEL, Kell metallo-endopeptidase (Kell blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KEL, Kell metallo-endopeptidase (Kell blood group)
  • Synonyms
    CD238, ECE3, Kell
  • Links
    NCBI Gene ID: 3792
    neXtProt AC: NX_P23276
    UniProt: P23276

  • Chr Location
    7q34; chr7:142941114-142962363 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased heart rate, altered hematological parameters and ECG waveform features, decreased erythrocyte Mg2+ and K+ ion content, mild motor deficits, and giant axon changes with varying degrees of paranodal demyelination in the spinal cord and sciatic nerve.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23925 NCBI Gene Model | MGI Sequence Detail 18006 C57BL/6J ±  kb
    transcript NM_032540 RefSeq | MGI Sequence Detail 2524 ZRU/MplStud  
    polypeptide Q9EQF2 UniProt | EBI | MGI Sequence Detail 713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 29
      Gene Ontology 10
      Phenotypes 5
    • Earliest
      J:69072 Lee S, et al., The mouse Kell blood group gene (Kel): cDNA sequence, genomic organization, expression, and enzymatic function. Immunogenetics. 2000 Nov;52(1-2):53-62
    • Latest
      J:343977 Maruyama T, et al., Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol. 2015 May;33(5):538-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory