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Tlr2 Gene Detail
Summary
  • Symbol
    Tlr2
  • Name
    toll-like receptor 2
  • Synonyms
    Ly105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346060
    NCBI Gene: 24088
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:83743579-83749045 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 37.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346060
 protein coding gene Chr3:83743579-83749074 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027337
 protein coding gene Chr3:83704326-83709822 (-)
A/J MGP_AJ_G0027301
 protein coding gene Chr3:80947540-80953035 (-)
AKR/J MGP_AKRJ_G0027267
 protein coding gene Chr3:82852325-82857820 (-)
BALB/cJ MGP_BALBcJ_G0027310
 protein coding gene Chr3:81017435-81022930 (-)
C3H/HeJ MGP_C3HHeJ_G0027054
 protein coding gene Chr3:83148214-83153709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027756
 protein coding gene Chr3:86842477-86847972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025109
 protein coding gene Chr3:76605003-76610527 (-)
CAST/EiJ MGP_CASTEiJ_G0026501
 protein coding gene Chr3:83335371-83340852 (-)
CBA/J MGP_CBAJ_G0027029
 protein coding gene Chr3:89768282-89773777 (-)
DBA/2J MGP_DBA2J_G0027165
 protein coding gene Chr3:80468091-80473586 (-)
FVB/NJ MGP_FVBNJ_G0027133
 protein coding gene Chr3:78753061-78758556 (-)
LP/J MGP_LPJ_G0027273
 protein coding gene Chr3:84673398-84678894 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027152
 protein coding gene Chr3:96143464-96148959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027814
 protein coding gene Chr3:82646608-82652104 (-)
PWK/PhJ MGP_PWKPhJ_G0026235
 protein coding gene Chr3:80230609-80236220 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026051
 protein coding gene Chr3:81827332-81832839 (-)
WSB/EiJ MGP_WSBEiJ_G0026579
 protein coding gene Chr3:83001018-83006513 (-)



Homology
more
  • Human Ortholog
    TLR2, toll like receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR2, toll like receptor 2
  • Synonyms
    CD282, TIL4
  • Links
    NCBI Gene ID: 7097
    neXtProt AC: NX_O60603
    UniProt: O60603

  • Chr Location
    4q31.3; chr4:153684050-153710637 (+)  GRCh38
Human Diseases
more
  • Diseases
    23 with human TLR2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 "NOT" model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    121 phenotypes from 4 alleles in 13 genetic backgrounds
    19 phenotypes from multigenic genotypes
    1066 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice demonstrate abnormal responses to bacterial and viral infections. Mice homozygous for a knock-out allele also exhibit disruption in circadian active and inactive state consolidation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    141
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    903
  • Tissues
    113
  • cDNA Data
    23
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24088 NCBI Gene Model | MGI Sequence Detail 5467 C57BL/6J ±  kb
    transcript NM_011905 RefSeq | MGI Sequence Detail 2874 C57BL/6  
    polypeptide Q9QUN7 UniProt | EBI | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 23
      Primer pair 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 1450
      Developmental Gene Expression 20
      Diseases 2
      Gene Ontology 33
      Phenotypes 1066
    • Earliest
      J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
    • Latest
      J:357521 Cui H, et al., TLR2/NF-kappaB signaling in macrophage/microglia mediated COVID-pain induced by SARS-CoV-2 envelope protein. iScience. 2024 Oct 18;27(10):111027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory