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Twf2 Gene Detail
Summary
  • Symbol
    Twf2
  • Name
    twinfilin actin binding protein 2
  • Synonyms
    A6-related, Ptk9l, Twf2, Twinfilin-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346078
    NCBI Gene: 23999
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106080307-106092586 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    337 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346078
 protein coding gene Chr9:106080307-106092588 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035223
 protein coding gene Chr9:107984933-108000159 (+)
A/J MGP_AJ_G0035203
 protein coding gene Chr9:104098141-104110615 (+)
AKR/J MGP_AKRJ_G0035135
 protein coding gene Chr9:106688271-106700508 (+)
BALB/cJ MGP_BALBcJ_G0035196
 protein coding gene Chr9:103780261-103793215 (+)
C3H/HeJ MGP_C3HHeJ_G0034906
 protein coding gene Chr9:107095768-107108886 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035716
 protein coding gene Chr9:110948380-110961865 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032614
 protein coding gene Chr9:101592592-101605054 (+)
CAST/EiJ MGP_CASTEiJ_G0034218
 protein coding gene Chr9:106985763-106999467 (+)
CBA/J MGP_CBAJ_G0034875
 protein coding gene Chr9:114849725-114866450 (+)
DBA/2J MGP_DBA2J_G0035036
 protein coding gene Chr9:103556320-103569348 (+)
FVB/NJ MGP_FVBNJ_G0034984
 protein coding gene Chr9:102329034-102341714 (+)
LP/J MGP_LPJ_G0035112
 protein coding gene Chr9:108211963-108226993 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035023
 protein coding gene Chr9:116506309-116521012 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035738
 protein coding gene Chr9:106927174-106939816 (+)
PWK/PhJ MGP_PWKPhJ_G0033925
 protein coding gene Chr9:103850583-103863148 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033760
 protein coding gene Chr9:106985838-107000574 (+)
WSB/EiJ MGP_WSBEiJ_G0034338
 protein coding gene Chr9:106827648-106840118 (+)



Homology
more
  • Human Ortholog
    TWF2, twinfilin actin binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TWF2, twinfilin actin binding protein 2
  • Synonyms
    A6r, A6RP, MSTP011, PTK9L
  • Links
    NCBI Gene ID: 11344
    neXtProt AC: NX_Q6IBS0
    UniProt: Q6IBS0

  • Chr Location
    3p21.2; chr3:52228612-52246788 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 images
    15 phenotype references
Mice homozygous for a targeted allele are viable, fertile, and do not display obvious morphological or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    101
  • cDNA Data
    67
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 23999 NCBI Gene Model | MGI Sequence Detail 12280 C57BL/6J ±  kb
transcript NM_011876 RefSeq | MGI Sequence Detail 1594 C57BL/6  
polypeptide Q9Z0P5 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 67
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143188
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:56491 Rohwer A, et al., Cloning, expression and characterization of an A6-related protein. Eur J Biochem. 1999 Jul;263(2):518-25
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory