Aplnr MGI Mouse Gene Detail - MGI:1346086

Symbol

Aplnr
Name

apelin receptor
Synonyms

Agtrl1, apelin receptor, APJ, msr/apj

Feature Type

protein coding gene
IDs

MGI:1346086
NCBI Gene: 23796
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:84966704-84970267 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 49.45 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

136 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346086	protein coding gene	Chr2:84966569-84970267 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025922	protein coding gene	Chr2:85847149-85850847 (+)
A/J	MGP_AJ_G0025896	protein coding gene	Chr2:82511995-82515696 (+)
AKR/J	MGP_AKRJ_G0025866	protein coding gene	Chr2:84645253-84648954 (+)
BALB/cJ	MGP_BALBcJ_G0025893	protein coding gene	Chr2:82642815-82646516 (+)
C3H/HeJ	MGP_C3HHeJ_G0025652	protein coding gene	Chr2:84878782-84882483 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026339	protein coding gene	Chr2:88494503-88498201 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023741	protein coding gene	Chr2:79335941-79339670 (+)
CAST/EiJ	MGP_CASTEiJ_G0025113	protein coding gene	Chr2:85431782-85435478 (+)
CBA/J	MGP_CBAJ_G0025633	protein coding gene	Chr2:91644354-91648055 (+)
DBA/2J	MGP_DBA2J_G0025764	protein coding gene	Chr2:82047989-82051690 (+)
FVB/NJ	MGP_FVBNJ_G0025727	protein coding gene	Chr2:81303166-81306855 (+)
LP/J	MGP_LPJ_G0025852	protein coding gene	Chr2:85628714-85632415 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025757	protein coding gene	Chr2:93957067-93960759 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026395	protein coding gene	Chr2:84889679-84893371 (+)
PWK/PhJ	MGP_PWKPhJ_G0024857	protein coding gene	Chr2:81897948-81901637 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024661	protein coding gene	Chr2:85017928-85021628 (+)
WSB/EiJ	MGP_WSBEiJ_G0025183	protein coding gene	Chr2:85549144-85552842 (+)

Human Ortholog

APLNR, apelin receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APLNR, apelin receptor
Synonyms

AGTRL1, APJ, APJR, HG11
Links

HGNC:339

NCBI Gene ID: 187

neXtProt AC: NX_P35414

UniProt: P35414
Chr Location

11q12.1; chr11:57233577-57237250 (-) GRCh38

MGI Vertebrate Homology

Aplnr stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: APLNR
Gene Tree

Aplnr

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Phenotype Summary

24 phenotypes from 6 alleles in 6 genetic backgrounds
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

9
Targeted

11
Genomic Mutations

3 involving Aplnr
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit early lethality, decreased cardiac contractility, and decreased exercise endurance. Mice for another knock-out allele develop pulmonary venoocclusive disease with heart right ventricle hypertrophy and elevated pulmonary pressures.

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All GO Annotations

43
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

927
Tissues

124
cDNA Data

42
Literature Summary

41

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aplnr

ZFIN aplnra, aplnrb

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All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS16201.1

Ensembl

ENSMUSG00000044338 (Evidence)
NCBI Gene

23796

			Length	Strain/Species	Flank
genomic	23796	NCBI Gene Model \| MGI Sequence Detail	3564	C57BL/6J	± kb
transcript	NM_011784	RefSeq \| MGI Sequence Detail	3573	C57BL/6
polypeptide	Q9WV08	UniProt \| EBI \| MGI Sequence Detail	377	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001120 apelin receptor

(term hierarchy)
InterPro Domains

IPR003904 Apelin receptor

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q9WV08 2 sites

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All nucleic 47

cDNA 44

Other 3

Microarray probesets 5

Summaries

All 119

Developmental Gene Expression 41

Gene Ontology 9

Phenotypes 46
Earliest

J:56817 Devic E, et al., Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. Mech Dev. 1999 Jun;84(1-2):199-203
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aplnr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18731	Chr2:84966687-84966698 (+)	-11 bp
Tssr18732	Chr2:84966699-84966715 (+)	3 bp
Tssr18733	Chr2:84966718-84966783 (+)	47 bp
Tssr18734	Chr2:84966792-84966803 (+)	94 bp
Tssr18735	Chr2:84966814-84966825 (+)	116 bp
Tssr18736	Chr2:84966866-84966875 (+)	167 bp
Tssr18737	Chr2:84966885-84966890 (+)	184 bp
Tssr18738	Chr2:84966944-84966967 (+)	252 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24