Sh3yl1 MGI Mouse Gene Detail - MGI:1346118

Symbol

Sh3yl1
Name

Sh3 domain YSC-like 1
Synonyms

Ray, YSC84

Feature Type

protein coding gene
IDs

MGI:1346118
NCBI Gene: 24057
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:30961667-31010161 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.01 cM
Mapping Data

1 experiment

SNPs within 2kb

1418 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346118	protein coding gene	Chr12:30961622-31010161 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019655	protein coding gene	Chr12:28834060-28887078 (+)
A/J	MGP_AJ_G0019622	protein coding gene	Chr12:28024657-28074883 (+)
AKR/J	MGP_AKRJ_G0019593	protein coding gene	Chr12:28927658-28977830 (+)
BALB/cJ	MGP_BALBcJ_G0019599	protein coding gene	Chr12:28270039-28317794 (+)
C3H/HeJ	MGP_C3HHeJ_G0019403	protein coding gene	Chr12:28793563-28845250 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020046	protein coding gene	Chr12:29727024-29779582 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017671	protein coding gene	Chr12:27345381-27389627 (+)
CAST/EiJ	MGP_CASTEiJ_G0018958	protein coding gene	Chr12:23791597-23851017 (+)
CBA/J	MGP_CBAJ_G0019374	protein coding gene	Chr12:30701804-30760225 (+)
DBA/2J	MGP_DBA2J_G0019488	protein coding gene	Chr12:27865399-27914956 (+)
FVB/NJ	MGP_FVBNJ_G0019479	protein coding gene	Chr12:27659191-27709083 (+)
LP/J	MGP_LPJ_G0019558	protein coding gene	Chr12:28932600-28982340 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019514	protein coding gene	Chr12:30325907-30384734 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020086	protein coding gene	Chr12:28447663-28498299 (+)
PWK/PhJ	MGP_PWKPhJ_G0018725	protein coding gene	Chr12:22598435-22654350 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018513	protein coding gene	Chr12:23068768-23118927 (+)
WSB/EiJ	MGP_WSBEiJ_G0019008	protein coding gene	Chr12:28688231-28738820 (+)

Human Ortholog

SH3YL1, SH3 and SYLF domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH3YL1, SH3 and SYLF domain containing 1
Synonyms

RAY
Links

HGNC:29546

NCBI Gene ID: 26751

neXtProt AC: NX_Q96HL8

UniProt: Q96HL8
Chr Location

2p25.3; chr2:217730-266398 (-) GRCh38

MGI Vertebrate Homology

Sh3yl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SH3YL1
Gene Tree

Sh3yl1

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout suppresses inflammatory reactions and reduces susceptibility to LPS-induced acute kidney disease.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

43

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sh3yl1

ZFIN sh3yl1

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All Sequences

46
RefSeq

7
UniProt

1
CCDS

CCDS25859.1, CCDS79110.1

Ensembl

ENSMUSG00000020669 (Evidence)
NCBI Gene

24057

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020669	Ensembl Gene Model \| MGI Sequence Detail	48495	C57BL/6J	± kb
transcript	ENSMUST00000020997	Ensembl \| MGI Sequence Detail	1750	Not Applicable
polypeptide	ENSMUSP00000020997	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030844 SH3 domain-containing YSC84-like protein 1

(term hierarchy)
InterPro Domains

IPR001452 SH3 domain

IPR051702 SH3 domain-containing protein YSC84-like

IPR036028 SH3-like domain superfamily

IPR033643 SH3YL1-like, SYLF domain

IPR035511 SH3YL1, SH3 domain

IPR007461 Ysc84 actin-binding domain

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All nucleic 43

cDNA 43

Microarray probesets 3

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MGI:2144784

Summaries

All 28

Gene Ontology 4

Phenotypes 6
Earliest

J:62054 Aoki N, et al., A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle. J Invest Dermatol. 2000 May;114(5):1050-6
Latest

J:353243 Lee SR, et al., Nox4-SH3YL1 complex is involved in diabetic nephropathy. iScience. 2024 Feb 16;27(2):108868

TSS for Sh3yl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113092	Chr12:30960543-30960555 (+)	-1,118 bp
Tssr113093	Chr12:30960558-30960576 (+)	-1,100 bp
Tssr113094	Chr12:30961658-30961732 (+)	28 bp
Tssr113095	Chr12:30961774-30961785 (+)	113 bp
Tssr113096	Chr12:30962158-30962199 (+)	512 bp
Tssr113097	Chr12:31003624-31003628 (+)	41,959 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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