Nr1i3 MGI Mouse Gene Detail - MGI:1346307 - nuclear receptor subfamily 1, group I, member 3

Symbol

Nr1i3
Name

nuclear receptor subfamily 1, group I, member 3
Synonyms

CAR, CAR1, Care2, ESTM32, MB67, mCAR

Feature Type

protein coding gene
IDs

MGI:1346307
NCBI Gene: 12355
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:171041503-171046414 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.21 cM
Mapping Data

5 experiments

SNPs within 2kb

180 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346307	protein coding gene	Chr1:171041503-171048270 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016745	protein coding gene	Chr1:176994769-177001504 (+)
A/J	MGP_AJ_G0016725	protein coding gene	Chr1:169795445-169802171 (+)
AKR/J	MGP_AKRJ_G0016691	protein coding gene	Chr1:174878628-174885359 (+)
BALB/cJ	MGP_BALBcJ_G0016686	protein coding gene	Chr1:170277929-170284664 (+)
C3H/HeJ	MGP_C3HHeJ_G0016509	protein coding gene	Chr1:175126020-175132755 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017147	protein coding gene	Chr1:182878365-182885096 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014855	protein coding gene	Chr1:161475504-161482227 (+)
CAST/EiJ	MGP_CASTEiJ_G0016090	protein coding gene	Chr1:174750269-174757000 (+)
CBA/J	MGP_CBAJ_G0016484	protein coding gene	Chr1:189390034-189396769 (+)
DBA/2J	MGP_DBA2J_G0016591	protein coding gene	Chr1:168634325-168641060 (+)
FVB/NJ	MGP_FVBNJ_G0016587	protein coding gene	Chr1:166983397-166990129 (+)
LP/J	MGP_LPJ_G0016662	protein coding gene	Chr1:178115974-178122709 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016614	protein coding gene	Chr1:196676070-196682805 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017184	protein coding gene	Chr1:174751401-174758127 (+)
PWK/PhJ	MGP_PWKPhJ_G0015876	protein coding gene	Chr1:167857306-167864032 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015660	protein coding gene	Chr1:173536568-173543226 (+)
WSB/EiJ	MGP_WSBEiJ_G0016152	protein coding gene	Chr1:174869814-174876541 (+)

Human Ortholog

NR1I3, nuclear receptor subfamily 1 group I member 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NR1I3, nuclear receptor subfamily 1 group I member 3
Synonyms

CAR, CAR1, MB67
Links

HGNC:7969

NCBI Gene ID: 9970

neXtProt AC: NX_Q14994

UniProt: Q14994
Chr Location

1q23.3; chr1:161229666-161238244 (-) GRCh38

MGI Vertebrate Homology

Nr1i3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NR1I3
Gene Tree

Nr1i3

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Phenotype Summary

11 phenotypes from 3 alleles in 5 genetic backgrounds
7 phenotypes from multigenic genotypes
90 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

9
Genomic Mutations

2 involving Nr1i3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased sensitivity to TCPOBOP.

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All GO Annotations

37
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

71
cDNA Data

12
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nr1i3

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All Sequences

60
RefSeq

12
UniProt

5
CCDS

CCDS15480.1, CCDS56654.1, CCDS56655.1

Ensembl

ENSMUSG00000005677 (Evidence)
NCBI Gene

12355

			Length	Strain/Species	Flank
genomic	12355	NCBI Gene Model \| MGI Sequence Detail	4912	C57BL/6J	± kb
transcript	NM_009803	RefSeq \| MGI Sequence Detail	1428	ZRU/MplStud
polypeptide	O35627	UniProt \| EBI \| MGI Sequence Detail	358	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011398 nuclear receptor subfamily 1 group I member 3

(term hierarchy)
PDB

1XLS, 1XNX
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR050234 Nuclear hormone receptor family NR1 subfamily

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR001728 Thyroid hormone receptor

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type

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All nucleic 18

Genomic 1

cDNA 12

Primer pair 4

Other 1

Microarray probesets 4

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MGI:1313311, MGI:1334464, MGI:2138288

Summaries

All 170

Developmental Gene Expression 10

Gene Ontology 10

Phenotypes 90
Earliest

J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
Latest

J:347001 Yang X, et al., Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem. 2023 Jan 30;299(3):102955

TSS for Nr1i3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9983	Chr1:171041538-171041576 (+)	54 bp
Tssr9984	Chr1:171041582-171041614 (+)	95 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24