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Gpc6 Gene Detail
Summary
  • Symbol
    Gpc6
  • Name
    glypican 6
  • Synonyms
    6720429C22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346322
    NCBI Gene: 23888
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:117162727-118213956 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 60.34 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34732 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346322
 protein coding gene Chr14:117162332-118216941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021645
 protein coding gene Chr14:114441571-115535212 (+)
A/J MGP_AJ_G0021604
 protein coding gene Chr14:110107054-111133634 (+)
AKR/J MGP_AKRJ_G0021580
 protein coding gene Chr14:113675078-114742659 (+)
BALB/cJ MGP_BALBcJ_G0021610
 protein coding gene Chr14:110611562-111675284 (+)
C3H/HeJ MGP_C3HHeJ_G0021388
 protein coding gene Chr14:113530810-114619341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022050
 protein coding gene Chr14:118895467-120008116 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019589
 protein coding gene Chr14:106192549-107209588 (+)
CAST/EiJ MGP_CASTEiJ_G0020904
 protein coding gene Chr14:111343774-112455434 (+)
CBA/J MGP_CBAJ_G0021356
 protein coding gene Chr14:123483249-124628155 (+)
DBA/2J MGP_DBA2J_G0021479
 protein coding gene Chr14:110004998-111059529 (+)
FVB/NJ MGP_FVBNJ_G0021457
 protein coding gene Chr14:108339937-109392857 (+)
LP/J MGP_LPJ_G0021547
 protein coding gene Chr14:115489543-116568183 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021484
 protein coding gene Chr14:128550188-129703930 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022073
 protein coding gene Chr14:113101975-114202988 (+)
PWK/PhJ MGP_PWKPhJ_G0020648
 protein coding gene Chr14:106988783-108044745 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020486
 protein coding gene Chr14:109351134-110446443 (+)
WSB/EiJ MGP_WSBEiJ_G0020959
 protein coding gene Chr14:113914097-115002416 (+)



Homology
more
  • Human Ortholog
    GPC6, glypican 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPC6, glypican 6
  • Synonyms
    OMIMD1
  • Links
    NCBI Gene ID: 10082
    neXtProt AC: NX_Q9Y625
    UniProt: Q9Y625

  • Chr Location
    13q31.3-q32.1; chr13:93216529-94408020 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPC6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, decreased fetal weight, short long bones, small skull, small snout, cleft palate and decreased chondrocyte proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    95
  • cDNA Data
    49
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058571 Ensembl Gene Model | MGI Sequence Detail 1051230 C57BL/6J ±  kb
    transcript ENSMUST00000125435 Ensembl | MGI Sequence Detail 2423 Not Applicable  
    polypeptide ENSMUSP00000120362 Ensembl | MGI Sequence Detail 565 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 49
      Primer pair 4
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1924985, MGI:2145665
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 22
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:57579 Veugelers M, et al., Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans. J Biol Chem. 1999 Sep 17;274(38):26968-77
    • Latest
      J:348792 Mead TJ, et al., Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development. Matrix Biol. 2024 May 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory