Fyb1 Gene Detail

Summary

• Symbol
  Fyb1
• Name
  FYN binding protein 1
• Synonyms
  ADAP, B630013F22Rik, Fyb, FYB-120/130

• Feature Type
  protein coding gene
• IDs
  MGI:1346327
  NCBI Gene: 23880
• Alliance
  gene page
• Transcription Start Sites
  62 TSS

Location &
Maps

• Sequence Map
  Chr15:6552334-6692794 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 3.19 cM, cytoband A1
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  4011 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346327	protein coding gene	Chr15:6552280-6695089 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021697	protein coding gene	Chr15:3542662-3648227 (+)
A/J	MGP_AJ_G0021658	protein coding gene	Chr15:3485555-3585208 (+)
AKR/J	MGP_AKRJ_G0021636	protein coding gene	Chr15:3500399-3599425 (+)
BALB/cJ	MGP_BALBcJ_G0021665	protein coding gene	Chr15:3399511-3498309 (+)
C3H/HeJ	MGP_C3HHeJ_G0021441	protein coding gene	Chr15:3526275-3630063 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022104	protein coding gene	Chr15:3710188-3810412 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019641	protein coding gene	Chr15:3154457-3234702 (+)
CAST/EiJ	MGP_CASTEiJ_G0020957	protein coding gene	Chr15:3508939-3612681 (+)
CBA/J	MGP_CBAJ_G0021410	protein coding gene	Chr15:3760762-3876520 (+)
DBA/2J	MGP_DBA2J_G0021534	protein coding gene	Chr15:3416814-3515863 (+)
FVB/NJ	MGP_FVBNJ_G0021512	protein coding gene	Chr15:3341552-3445628 (+)
LP/J	MGP_LPJ_G0021602	protein coding gene	Chr15:3468358-3572162 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021537	protein coding gene	Chr15:3978776-4089317 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022127	protein coding gene	Chr15:3518730-3625536 (+)
PWK/PhJ	MGP_PWKPhJ_G0020700	protein coding gene	Chr15:3424485-3524539 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020538	protein coding gene	Chr15:3438694-3536497 (+)
WSB/EiJ	MGP_WSBEiJ_G0021013	protein coding gene	Chr15:3451214-3557855 (+)

Homology

• Human Ortholog
  FYB1, FYN binding protein 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FYB1, FYN binding protein 1
  
• Synonyms
  ADAP, FYB, PRO0823, SLAP-130, SLAP130, THC3
• Links
  HGNC:4036

  NCBI Gene ID: 2533

  neXtProt AC: NX_O15117

  UniProt: O15117

  
  
• Chr Location
  5p13.1; chr5:39105252-39274528 (-)  GRCh38

---

• MGI Vertebrate Homology
  Fyb1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FYB1
• Gene Tree
  Fyb1
  

Human Diseases

• Diseases
  1 with human FYB1 associations

				Human Disease	Mouse Models
				thrombocytopenia IDs thrombocytopenia       DOID:1588 ICD10CM:D69.6 ICD9CM:287.5 MESH:D013921 OMIM:188000 OMIM:273900 OMIM:300367 OMIM:313900 OMIM:612004 ORDO:852 UMLS_CUI:C0040034

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 2 alleles in 3 genetic backgrounds
  43 phenotype references
  

• All Mutations and Alleles
  9
• Gene trapped
  2
• Targeted
  7
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  42 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  18
• GO References
  11

Expression

• Assay Results
  712
• Tissues
  1
• cDNA Data
  193
• Literature Summary
  1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  70
• RefSeq
  18
• UniProt
  7
• CCDS
  CCDS37031.1

• Ensembl
  ENSMUSG00000022148 (Evidence)
• NCBI Gene
  23880

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000022148	Ensembl Gene Model | MGI Sequence Detail	140461	C57BL/6J
transcript	ENSMUST00000090461	Ensembl | MGI Sequence Detail	2669	Not Applicable
polypeptide	ENSMUSP00000087947	Ensembl | MGI Sequence Detail	819	Not Applicable

Protein
Information

• UniProt
  7 Sequences
• Protein Ontology
  PR:000007717 FYN-binding protein 1
  (term hierarchy)
• InterPro Domains
  IPR035540 FYB, helically extended SH3 domain
  IPR043443 FYN-binding protein 1/2-like
  IPR029294 Helically-extended SH3 domain
  IPR001452 SH3 domain
  IPR036028 SH3-like domain superfamily

Molecular
Reagents

• All nucleic 197

  cDNA 197

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2443545, MGI:7525417

References

• Summaries
  All 87

  Developmental Gene Expression 1

  Gene Ontology 11

  Phenotypes 43
• Earliest
  J:41750 da Silva AJ, et al., Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7493-8
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fyb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130495	Chr15:6552270-6552348 (+)	-25 bp
Tssr130496	Chr15:6569739-6569751 (+)	17,411 bp
Tssr130497	Chr15:6569773-6569793 (+)	17,449 bp
Tssr130498	Chr15:6569794-6569810 (+)	17,468 bp
Tssr130499	Chr15:6569827-6569834 (+)	17,497 bp
Tssr130500	Chr15:6576949-6576974 (+)	24,628 bp
Tssr130501	Chr15:6581648-6581653 (+)	29,317 bp
Tssr130502	Chr15:6598933-6598940 (+)	46,603 bp
Tssr130503	Chr15:6598962-6598978 (+)	46,636 bp
Tssr130504	Chr15:6598980-6598996 (+)	46,654 bp
Tssr130505	Chr15:6599002-6599034 (+)	46,684 bp
Tssr130506	Chr15:6599039-6599046 (+)	46,709 bp
Tssr130507	Chr15:6604264-6604295 (+)	51,946 bp
Tssr130508	Chr15:6608188-6608197 (+)	55,859 bp
Tssr130509	Chr15:6609173-6609184 (+)	56,845 bp
Tssr130510	Chr15:6609298-6609320 (+)	56,975 bp
Tssr130511	Chr15:6609322-6609363 (+)	57,009 bp
Tssr130512	Chr15:6609365-6609381 (+)	57,039 bp
Tssr130513	Chr15:6609407-6609418 (+)	57,079 bp
Tssr130514	Chr15:6609444-6609455 (+)	57,116 bp
Tssr130515	Chr15:6609462-6609471 (+)	57,133 bp
Tssr130516	Chr15:6609497-6609508 (+)	57,169 bp
Tssr130517	Chr15:6609552-6609561 (+)	57,223 bp
Tssr130518	Chr15:6609637-6609648 (+)	57,309 bp
Tssr130519	Chr15:6609692-6609699 (+)	57,362 bp
Tssr130520	Chr15:6609759-6609777 (+)	57,434 bp
Tssr130521	Chr15:6609826-6609835 (+)	57,497 bp
Tssr130522	Chr15:6609874-6609885 (+)	57,546 bp
Tssr130523	Chr15:6610016-6610025 (+)	57,687 bp
Tssr130524	Chr15:6610056-6610067 (+)	57,728 bp
Tssr130525	Chr15:6610106-6610115 (+)	57,777 bp
Tssr130526	Chr15:6610156-6610161 (+)	57,825 bp
Tssr130527	Chr15:6610359-6610381 (+)	58,036 bp
Tssr130528	Chr15:6610417-6610431 (+)	58,090 bp
Tssr130529	Chr15:6610441-6610460 (+)	58,117 bp
Tssr130530	Chr15:6610466-6610477 (+)	58,138 bp
Tssr130531	Chr15:6610494-6610505 (+)	58,166 bp
Tssr130532	Chr15:6610536-6610548 (+)	58,208 bp
Tssr130533	Chr15:6622328-6622339 (+)	70,000 bp
Tssr130534	Chr15:6622360-6622370 (+)	70,031 bp
Tssr130535	Chr15:6627340-6627351 (+)	75,012 bp
Tssr130536	Chr15:6628854-6628888 (+)	76,537 bp
Tssr130537	Chr15:6628932-6628959 (+)	76,612 bp
Tssr130538	Chr15:6629202-6629205 (+)	76,870 bp
Tssr130539	Chr15:6637293-6637294 (+)	84,960 bp
Tssr130540	Chr15:6649077-6649112 (+)	96,761 bp
Tssr130541	Chr15:6649159-6649189 (+)	96,840 bp
Tssr130542	Chr15:6649190-6649207 (+)	96,865 bp
Tssr130543	Chr15:6659536-6659556 (+)	107,212 bp
Tssr130544	Chr15:6662343-6662364 (+)	110,020 bp
Tssr130545	Chr15:6663152-6663166 (+)	110,825 bp
Tssr130546	Chr15:6668462-6668476 (+)	116,135 bp
Tssr130547	Chr15:6672055-6672069 (+)	119,728 bp
Tssr130548	Chr15:6673168-6673187 (+)	120,844 bp
Tssr130549	Chr15:6673196-6673214 (+)	120,871 bp
Tssr130550	Chr15:6674235-6674273 (+)	121,920 bp
Tssr130551	Chr15:6674277-6674301 (+)	121,955 bp
Tssr130552	Chr15:6674302-6674314 (+)	121,974 bp
Tssr130553	Chr15:6674370-6674414 (+)	122,058 bp
Tssr130554	Chr15:6677120-6677132 (+)	124,792 bp
Tssr130555	Chr15:6677571-6677585 (+)	125,244 bp
Tssr130556	Chr15:6686018-6686044 (+)	133,697 bp