Xcr1 MGI Mouse Gene Detail - MGI:1346338 - chemokine (C motif) receptor 1

Symbol

Xcr1
Name

chemokine (C motif) receptor 1
Synonyms

Ccxcr1, C motif-1/lymphotactin receptor, GPR5, XCR1

Feature Type

protein coding gene
IDs

MGI:1346338
NCBI Gene: 23832
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:123681380-123691094 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 74.71 cM, cytoband F4
Mapping Data

3 experiments

SNPs within 2kb

499 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346338	protein coding gene	Chr9:123681380-123691094 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035485	protein coding gene	Chr9:126904374-126913423 (-)
A/J	MGP_AJ_G0035466	protein coding gene	Chr9:122059451-122069533 (-)
AKR/J	MGP_AKRJ_G0035399	protein coding gene	Chr9:125324674-125336246 (-)
BALB/cJ	MGP_BALBcJ_G0035462	protein coding gene	Chr9:121988392-121997611 (-)
C3H/HeJ	MGP_C3HHeJ_G0035169	protein coding gene	Chr9:125773660-125782786 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035985	protein coding gene	Chr9:130413618-130422777 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032867	protein coding gene	Chr9:119166215-119173984 (-)
CAST/EiJ	MGP_CASTEiJ_G0034474	protein coding gene	Chr9:125825743-125835140 (-)
CBA/J	MGP_CBAJ_G0035137	protein coding gene	Chr9:135177861-135188430 (-)
DBA/2J	MGP_DBA2J_G0035296	protein coding gene	Chr9:121499930-121509296 (-)
FVB/NJ	MGP_FVBNJ_G0035243	protein coding gene	Chr9:120403632-120414318 (-)
LP/J	MGP_LPJ_G0035375	protein coding gene	Chr9:127308695-127319132 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035284	protein coding gene	Chr9:135988385-135999850 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036004	protein coding gene	Chr9:125794115-125804466 (-)
PWK/PhJ	MGP_PWKPhJ_G0034178	protein coding gene	Chr9:121959479-121969166 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034015	protein coding gene	Chr9:125895393-125904366 (-)
WSB/EiJ	MGP_WSBEiJ_G0034594	protein coding gene	Chr9:125626598-125637204 (-)

Human Ortholog

XCR1, X-C motif chemokine receptor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XCR1, X-C motif chemokine receptor 1
Synonyms

CCXCR1, GPR5
Links

HGNC:1625

NCBI Gene ID: 2829

neXtProt AC: NX_P46094

UniProt: P46094
Chr Location

3p21.31; chr3:46016990-46085844 (-) GRCh38

MGI Vertebrate Homology

Xcr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: XCR1
Gene Tree

Xcr1

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
65 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Targeted

11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a targeted null mutation exhibit reduced CD8+ dendritic cell migration in response to XCL1.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

94
cDNA Data

7
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

4
CCDS

CCDS23665.2

Ensembl

ENSMUSG00000060509 (Evidence)
NCBI Gene

23832

			Length	Strain/Species	Flank
genomic	23832	NCBI Gene Model \| MGI Sequence Detail	9715	C57BL/6J	± kb
transcript	NM_011798	RefSeq \| MGI Sequence Detail	4453	ZRU/MplStud
polypeptide	Q9R0M1	UniProt \| EBI \| MGI Sequence Detail	322	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001212 chemokine XC receptor 1

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR005393 XC chemokine receptor 1

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 3

Summaries

All 91

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 65
Earliest

J:57566 Yoshida T, et al., Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. FEBS Lett. 1999 Sep 10;458(1):37-40
Latest

J:355474 Mitchell JS, et al., CD4(+) T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes. Immunity. 2024 Oct 8;57(10):2399-2415.e8

TSS for Xcr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92177	Chr9:123691088-123691100 (-)	0 bp
Tssr92176	Chr9:123691078-123691085 (-)	12 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24