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Trex2 Gene Detail
Summary
  • Symbol
    Trex2
  • Name
    three prime repair exonuclease 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346343
    NCBI Gene: 24102
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72477311-72478949 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.31 cM, cytoband A6
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346343
 protein coding gene ChrX:72477311-72478950 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035809
 protein coding gene ChrX:69181195-69182834 (-)
A/J MGP_AJ_G0035790
 protein coding gene ChrX:69396544-69398183 (-)
AKR/J MGP_AKRJ_G0035715
 protein coding gene ChrX:71206148-71207787 (-)
BALB/cJ MGP_BALBcJ_G0035775
 protein coding gene ChrX:68431599-68433238 (-)
C3H/HeJ MGP_C3HHeJ_G0035480
 protein coding gene ChrX:69661528-69663167 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036305
 protein coding gene ChrX:71319930-71321569 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033149
 protein coding gene ChrX:68443359-68444989 (-)
CAST/EiJ MGP_CASTEiJ_G0034771
 protein coding gene ChrX:55011818-55013464 (-)
CBA/J MGP_CBAJ_G0035455
 protein coding gene ChrX:73258759-73260398 (-)
DBA/2J MGP_DBA2J_G0035612
 protein coding gene ChrX:68864332-68865971 (-)
FVB/NJ MGP_FVBNJ_G0035556
 protein coding gene ChrX:68190848-68192487 (-)
LP/J MGP_LPJ_G0035697
 protein coding gene ChrX:69988793-69990432 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035594
 protein coding gene ChrX:75855277-75856916 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036327
 protein coding gene ChrX:69010498-69012137 (-)
PWK/PhJ MGP_PWKPhJ_G0034470
 protein coding gene ChrX:53032394-53034040 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034304
 protein coding gene ChrX:55930642-55932278 (-)
WSB/EiJ MGP_WSBEiJ_G0034912
 protein coding gene ChrX:68288064-68289703 (-)



Homology
more
  • Human Ortholog
    TREX2, three prime repair exonuclease 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TREX2, three prime repair exonuclease 2
  • Links
    NCBI Gene ID: 11219
    neXtProt AC: NX_Q9BQ50
    UniProt: Q9BQ50

  • Chr Location
    Xq28; chrX:153444473-153470587 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to DMBA- or DMBA plus TPA-induced skin tumors associated with decreased apoptosis in treated epidermis and keratinocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24102 NCBI Gene Model | MGI Sequence Detail 1639 C57BL/6J ±  kb
transcript NM_011907 RefSeq | MGI Sequence Detail 1034 C57BL/6  
polypeptide Q9R1A9 UniProt | EBI | MGI Sequence Detail 236 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:56273 Mazur DJ, et al., Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases. J Biol Chem. 1999 Jul 9;274(28):19655-60
  • Latest
    J:268366 Cheng HL, et al., Structural insights into the duplex DNA processing of TREX2. Nucleic Acids Res. 2018 Dec 14;46(22):12166-12176
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory